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Source: Haematologica
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Total 41 results found since Jan 2013.
Variation and impact of polygenic hematological traits in monogenic sickle cell disease
Haematologica. 2022 Oct 13. doi: 10.3324/haematol.2022.281180. Online ahead of print.ABSTRACTSeveral complications observed in sickle cell disease (SCD) are influenced by variation in hematological traits (HT), such as fetal hemoglobin (HbF) level and neutrophil count. Previous large-scale genome-wide association studies carried out in largely healthy individuals have identified 1000s of variants associated with HT, which have then been used to develop multiancestry polygenic trait scores (PTS). Here, we tested if these PTS associate with HT in SCD patients and can improve statistical models associated with SCD-related com...
Source: Haematologica - October 13, 2022 Category: Hematology Authors: Thomas Pincez Ken Sin Lo Anne-Laure Pham Hung d'Alexandry D'Orengiani Melanie E Garrett Carlo Brugnara Allison E Ashley-Koch Marilyn J Telen Frederic Galacteros Philippe Joly Pablo Bartolucci Guillaume Lettre Source Type: research
Factors associated with left ventricular hypertrophy in children with sickle cell disease; results from the DISPLACE study
Haematologica. 2022 Apr 14. doi: 10.3324/haematol.2021.280480. Online ahead of print.ABSTRACTCardiopulmonary complications remain a leading cause of morbidity and mortality in sickle cell disease (SCD). The overall goals of this study were to evaluate the relationship between left ventricular hypertrophy (LVH) and laboratory markers of hemolysis and determine the association between LVH and SCD-specific therapies (Hydroxyurea and Chronic red cell transfusion). Data from DISPLACE (Dissemination and Implementation of Stroke Prevention Looking at the Care Environment) study cohort was used. LVH was defined based on the left v...
Source: Haematologica - April 14, 2022 Category: Hematology Authors: Najibah A Galadanci Walter Johnson April Carson Gerhard Hellemann Virginia Howard Julie Kanter Source Type: research
Complement dysregulation is associated with severe COVID-19 illness
Haematologica. 2021 Jul 22. doi: 10.3324/haematol.2021.279155. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia, reminiscent of other complement-mediated diseases. Multiple clinical and preclinical studies have implicated complement in the pathogenesis of COVID-19 illness. We previously found that the SARS-CoV-2 spike protein activates the alternative pathway of complement (APC) in vitro through interfering with the function of complement factor H, a key negative regulator of APC. Here, w...
Source: Haematologica - July 22, 2021 Category: Hematology Authors: Jia Yu Gloria F Gerber Hang Chen Xuan Yuan Shruti Chaturvedi Evan M Braunstein Robert A Brodsky Source Type: research
