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Stroke and the noncommunicable diseases: A global burden in need of global advocacy
Catalyzed by advocacy in the early period of the global AIDS crisis, the past decades have witnessed a revolution in global health funding, programs, and outcomes. In 2011, global HIV/AIDS programs received $7.7 billion of development assistance, amounting to 25% of total global health funding. In comparison, all noncommunicable diseases (NCDs) combined received only $377 million or 1.2% of global health funding, 20-fold less than HIV/AIDS funding.1 Taken together, NCDs cause an estimated 66% of yearly global mortality.2 The percentage of estimated total global mortality due to stroke (11.3%), a single NCD, exceeds that of...
Source: Neurology - May 25, 2015 Category: Neurology Authors: Berkowitz, A. L. Tags: Stroke prevention, All Cerebrovascular disease/Stroke GLOBAL PERSPECTIVES Source Type: research

Evaluating the performance of the PRISMA-7 frailty criteria for predicting disability and death after acute ischemic stroke
Stroke is the second cause of death and disability in the world, affecting close to 14 million people globally per year and being responsible for around 120 million disability-adjusted life years.1,2 More deaths occur worldwide because of stroke than AIDS, tuberculosis, and malaria combined.3 Therefore, being able to identify which individuals with stroke are at highest risk of poor function and mortality is critically important given the need for weighing the risks, costs, and benefits of interventions during various shared decision-making processes.
Source: Journal of Stroke and Cerebrovascular Diseases - October 22, 2022 Category: Neurology Authors: Luana Aparecida Miranda, Gustavo Jos é Luvizutto, Blossom Christa Maree Stephan, Juli Thomaz de Souza, Taís Regina da Silva, Fernanda Cristina Winckler, Natalia Cristina Ferreira, Leticia Claudia de Oliveira Antunes, Pedro Augusto Cândido Bessornia, Si Source Type: research

The global burden of neurologic diseases
WHO categorizes causes of death and disability into (1) communicable diseases, maternal and perinatal conditions, and nutritional deficiencies; (2) non-communicable diseases (NCD); and (3) injuries. NCD are the leading cause of death and disability globally and are rising as a result of demographic and epidemiologic changes occurring in both developed and developing countries.1,2 Increasing life expectancies, unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol contribute to the growing incidence and prevalence of NCD, such as heart disease, stroke, diabetes, cancers, and chronic respiratory disease...
Source: Neurology - July 21, 2014 Category: Neurology Authors: Chin, J. H., Vora, N. Tags: All Cerebrovascular disease/Stroke, All epidemiology, All Epilepsy/Seizures GLOBAL PERSPECTIVES Source Type: research

Chloroquine pretreatment attenuates ischemia-reperfusion injury in the brain of ob/ob diabetic mice as well as wildtype mice.
In conclusion, chloroquine pretreatment could reduce cerebral damage after ischemic stroke especially in diabetic mice through multiple mechanisms, which include reducing neural cell DNA injury, restoring euglycemia and anti-inflammatory effects. The findings may provide potential for the development of chloroquine in the prevention and treatment of stroke in diabetic high-risk patients. PMID: 31647899 [PubMed - as supplied by publisher]
Source: Brain Research - October 20, 2019 Category: Neurology Authors: Zhang YP, Cui QY, Zhang TM, Yi Y, Nie JJ, Xie GH, Wu JH Tags: Brain Res Source Type: research

Development of a Functional Scale for Progressive Multifocal Leukoencephalopathy: The NIH PML Scale (S10.005)
CONCLUSIONS: The NIH-PML scale provides a comprehensive functional assessment of the neurological status of this patient population. A specific clinical scale for PML will be important when evaluating future treatment strategies.Disclosure: Dr. Von Geldern has nothing to disclose. Dr. Cortese has nothing to disclose. Dr. Reich has nothing to disclose. Dr. Nath has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Von Geldern, G., Cortese, I., Ohayon, J., Reich, D., Nath, A. Tags: HIV, PML, and Cerebral Malaria Source Type: research

Clinical Associations of Cerebral Microbleeds on Magnetic Resonance Neuroimaging
Susceptibility-weighted and gradient-recalled echo T2* magnetic resonance imaging have enabled the detection of very small foci of blood within the brain, which have been termed “cerebral microbleeds.” These petechial intraparenchymal hemorrhages have begun to emerge as diagnostically and prognostically useful markers in a variety of disease states. Severe hypertension and cerebral amyloid angiopathy are perhaps the best established microhemorrhagic conditions from neuroimaging literature; however, many others are also recognized including cerebral autosomal dominant arteriopathy, subcortical infarcts, and leukoencepha...
Source: Journal of Stroke and Cerebrovascular Diseases - October 4, 2014 Category: Neurology Authors: Matthew Schrag, David M. Greer Tags: Review Article Source Type: research

Raising the curtain on cerebral malaria ’s deadly agents
Using state-of-the-art brain imaging technology, scientists at the National Institutes of Health filmed what happens in the brains of mice that developed cerebral malaria (CM). The results, published in PLOS Pathogens, reveal the processes that lead to fatal outcomes of the disease and suggest an antibody therapy that may treat it.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - December 6, 2016 Category: Neurology Source Type: news