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Source: Behavioural Brain Research

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Total 143 results found since Jan 2013.

Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway.
Abstract Post-stroke depression(PSD) is a common complication and associates with poor physical recovery, low quality of life and high mortality after cerebral infarction. However, the pathogenesis of PSD have not been elucidated thoroughly now, and there is a lack of effective therapy in clinic. It reported that Saikosaponin A, one of the main constituents from Chinese herb Bupleurum chinense, has pharmacological activity in anti-depression. Thus, this study aimed to elucidate the potential effects and mechanisms of Saikosaponin A on the depression-like behavior after cerebral ischemic injury in rats. The rat mod...
Source: Behavioural Brain Research - January 22, 2021 Category: Neurology Authors: Wang AR, Mi LF, Zhang ZL, Hu MZ, Zhao ZY, Liu B, Li YB, Zheng S Tags: Behav Brain Res Source Type: research

Effect of NEUROG3 Polymorphism Rs144643855 on Regional Spontaneous Brain Activity in Major Depressive Disorder
CONCLUSION: These findings suggest a potential relationship between rs144643855 variations and altered frontal brain activity in MDD. NEUROG3 may play an important role in the neuropathophysiology of MDD.PMID:33878431 | DOI:10.1016/j.bbr.2021.113310
Source: Behavioural Brain Research - April 20, 2021 Category: Neurology Authors: Zhuoliang Hou Xiaoyun Liu Wenhao Jiang Zhenghua Hou Yingying Yin Chunming Xie Haisan Zhang Hongxing Zhang Zhijun Zhang Yonggui Yuan Source Type: research

Specific stimulation of PV < sup > + < /sup > neurons at early stage ameliorates prefrontal ischemia-induced spatial working memory impairment
Behav Brain Res. 2021 Aug 3:113511. doi: 10.1016/j.bbr.2021.113511. Online ahead of print.ABSTRACTPrefrontal ischemia can cause impairments in learning and memory, executive functions and cognitive flexibility. However, the related cellular mechanisms at the early stage are still elusive. The present study used ischemic stroke in medial prefrontal cortex and systemically investigated the electrophysiological changes of the parvalbumin (PV+) interneurons 12 h post ischemia. We found that Ih and the related voltage sags in PV+ interneurons are downregulated post ischemia, which correlates with hyperpolarization of the membra...
Source: Behavioural Brain Research - August 6, 2021 Category: Neurology Authors: Lin Chen Jun Hu Jiankun Mu Chao Li Guang-Yan Wu Chao He Youhong Xie Jian-Ning Ye Source Type: research

Different training patterns at recovery stage improve cognitive function in ischemic stroke rats through regulation of the axonal growth inhibitor pathway
This study investigated the effects of SRT and RWE, at the recovery stage, on the cognitive function of transient middle cerebral artery occlusion (tMCAO) rats and explored their association with NgR1/Rho-A/ROCK/LOTUS/LGI1 signaling. Adult Sprague-Dawley rats (n = 55) were divided into four groups after pretraining: SRT, RWE, tMCAO, and Sham. Rats were subjected to modified neurological severity score (mNSS) measurements and forelimb grip strength and the Morris water maze tests. Using immunofluorescence and western blotting, we evaluated axonal growth inhibitor expression in the peri-infarct cortex on days 28 and 56 after...
Source: Behavioural Brain Research - December 31, 2021 Category: Neurology Authors: Chao Li Ruifang Sun Jiemei Chen Jiena Hong Ju Sun Yan Zeng Xue Zhang Zulin Dou Hongmei Wen Source Type: research

Impact of MRI on decision-making in ICU patients with disorders of consciousness
CONCLUSION: MRI results changed decision-making in 3 of 4 ICU patients, but radiological findings were not predictive of clinical decision-making. This highlights the need to better understand the effects of neuroimaging on management decisions. How MRI influences decision-making in the ICU is an important avenue for research to improve acute DoC management.PMID:34973968 | DOI:10.1016/j.bbr.2021.113729
Source: Behavioural Brain Research - January 2, 2022 Category: Neurology Authors: Simon S Albrechtsen Robert G C Riis Moshgan Amiri Gry Tanum Ove Bergdal Morten Blaabjerg Claus Z Simonsen Daniel Kondziella Source Type: research

Preserved Intersegmental Coordination During Locomotion after Cervical Spinal Cord Injury in Common Marmosets
In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegm...
Source: Behavioural Brain Research - March 1, 2022 Category: Neurology Authors: Yuta Sato Takahiro Kondo Akito Uchida Kenta Sato Kimika Yoshino-Saito Masaya Nakamura Hideyuki Okano Junichi Ushiba Source Type: research

Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets
In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegm...
Source: Behavioural Brain Research - March 1, 2022 Category: Neurology Authors: Yuta Sato Takahiro Kondo Akito Uchida Kenta Sato Kimika Yoshino-Saito Masaya Nakamura Hideyuki Okano Junichi Ushiba Source Type: research

Adipose-derived mesenchymal stem cells reduced transient cerebral ischemia injury by modulation of inflammatory factors and AMPK signaling
In this study, by releasing the clips, the reperfusion period was extended to 96hours, and two hours after cerebral ischemia, animals received adipose-derived MSCs. MSCs were isolated from the inguinal fat pads of rats and injected into two-vessel occlusion (2VO) rats 1hour after ischemia induction. Ninety-six hours after 2VO induction, behavioral and molecular tests were assessed. Adipose-derived MSCs treatment improves neurological scores, passive avoidance memory, and novel object recognition tests in the 2VO model compared to 2VO rats (P<0.001). MSCs treatment decreased TNF-α (P<0.01) and IL-6 (P<0.01) and ap...
Source: Behavioural Brain Research - July 9, 2022 Category: Neurology Authors: Mina Ranjbaran Reyhaneh Vaali Zahra Yaghoobi Fardin Sehati Vida Jashn Sevda Mahdipour Kolur Fariba Akhondzadeh Ghorbangol Ashabi Source Type: research

Disorders in the Gut and Liver are Involved in Depression Contagion Between Isosexual Post-stroke Depression Mice and the Healthy Cohabitors
Behav Brain Res. 2022 Dec 5:114246. doi: 10.1016/j.bbr.2022.114246. Online ahead of print.NO ABSTRACTPMID:36481213 | DOI:10.1016/j.bbr.2022.114246
Source: Behavioural Brain Research - December 8, 2022 Category: Neurology Authors: Hui Wang None Bin Wang Mei-Bo Pan Su-Ting Jiang Yi-Chen Wang Ying Zhu Qi-Chun Zhang Yin-Feng Dong Source Type: research

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