Filtered By:
Source: Behavioural Brain Research

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 143 results found since Jan 2013.

Training in a cooperative bimanual skilled reaching task, the popcorn retrieval task, improves unimanual function after motor cortical infarcts in rats.
Abstract Disuse of the paretic hand after stroke is encouraged by compensatory reliance on the nonparetic hand, to exacerbate impairment and potentially constrain motor rehabilitation efficacy. Rodent stroke model findings support that learning new unimanual skills with the nonparetic forelimb diminishes functional improvements that can be driven by rehabilitative training of the paretic forelimb. The influence of learning new ways of skillfully using the two hands together on paretic side function is much less clear. To begin to explore this, we developed a new cooperative bimanual skilled reaching task for rats,...
Source: Behavioural Brain Research - September 13, 2020 Category: Neurology Authors: Dutcher AM, Truong KV, Miller DD, Allred RP, Nudi E, Jones TA Tags: Behav Brain Res Source Type: research

Intensive treadmill training promotes cognitive recovery after cerebral ischemia-reperfusion in juvenile rats.
Abstract Rehabilitation training is routine for children who experience stroke, but its protective mechanism remains unclear. To study the effect of treadmill training intensity on hippocampal synaptic plasticity after cerebral ischemia, a model of middle cerebral artery occlusion (MCAO)/reperfusion was established in young rats to simulate childhood ischemic stroke. The rats were randomly allocated into five groups: sham operation, MCAO, low-intensity exercise and MCAO (5 m/min), medium-intensity exercise and MCAO (10 m/min), and high-intensity exercise and MCAO (15 m/min). Intervention was continued for 14...
Source: Behavioural Brain Research - December 21, 2020 Category: Neurology Authors: Pan G, Cheng J, Shen W, Lin Y, Zhu A, Jin L, Xie Q, Zhu M, Liu C, Tu F, Chen X Tags: Behav Brain Res Source Type: research

CRS induces depression-like behavior after MCAO in rats possibly by activating p38 MAPK
Behav Brain Res. 2022 Sep 10:114104. doi: 10.1016/j.bbr.2022.114104. Online ahead of print.ABSTRACTPost-stroke depression (PSD) is a common neuropsychiatric complication of stroke, which seriously affects the quality of life and prognosis of patients. Nevertheless, the pathogenesis of PSD remains unclear. In our study, a PSD rat model was established by chronic restraint stress (CRS) combined with middle cerebral artery occlusion (MCAO). Depressive and anxiety-like behaviors were tested, as well as Neuronal loss and Apoptosis. The expression of synapse and p38 MAPK signaling pathway -relevant proteins was detected. Our dat...
Source: Behavioural Brain Research - September 13, 2022 Category: Neurology Authors: Lingyun Zhi Fuping Zhang Huanhuan Liu Xinhui Jiang Yunfei Zhang Qianling Yang Xinyue Zhang Mengke Liu Zhaohui Zhang Jinggui Song Source Type: research

Effects of HF-rTMS on microglial polarization and white matter integrity in rats with poststroke cognitive impairment
This study aimed to evaluate the effect of 10 and 20Hz HF-rTMS on PSCI and the possible mechanisms. An ischemic stroke rat model was established by transient middle cerebral artery occlusion (tMCAO). The modified neurological deficit score (mNSS) and Morris water maze tests were conducted to assess neurological function and cognitive function. Luxol Fast Blue (LFB) staining was performed to evaluate white matter damage. Proinflammatory and anti-inflammatory cytokines were measured using enzyme-linked immunosorbent assays (ELISA). Immunofluorescence was used to assess microglial activation and polarization. Western blotting...
Source: Behavioural Brain Research - December 1, 2022 Category: Neurology Authors: Jiemei Chen Yan Zeng Jiena Hong Chao Li Xue Zhang Hongmei Wen Source Type: research

Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia.
Abstract Willed-movement (WM) training has been implicated in the promotion of motor function in human stroke survivors and focal ischemic rats. However, the molecular basis of changes in synaptic transmission following WM training remains unclear. In addition, studies examining the influence of rehabilitative training, such as skilled motor learning, on long-term depression (LTD) of synapses in the primary motor cortex have produced conflicting results. To identify the possible effects of willed movement on motor recovery, on expression of the protein interacting with C kinase 1 protein (PICK1), and on PICK1 rela...
Source: Behavioural Brain Research - September 1, 2013 Category: Neurology Authors: Tang Q, Tan L, Yang X, Shen Q, Huang X, Wang G, Chen H, Nie J, Li S, Wu L Tags: Behav Brain Res Source Type: research

Assessment of behavioral flexibility after middle cerebral artery occlusion in mice.
In conclusion, our operant-based task revealed a long-lasting behavioral flexibility deficit after MCAO in mice. PMID: 24157337 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - October 21, 2013 Category: Neurology Authors: Linden J, Fassotte L, Tirelli E, Plumier JC, Ferrara A Tags: Behav Brain Res Source Type: research

Human bone marrow mesenchymal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery.
In conclusion, human BMMSCs did not improve functional recovery in MCAO rats despite effective initial homing to the ischemic hemisphere and enhanced angiogenesis, when strict behavioral tests not affected by repeated testing and compensation were utilized. PMID: 24177208 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - October 28, 2013 Category: Neurology Authors: Mitkari B, Nitzsche F, Kerkelä E, Kuptsova K, Huttunen J, Nystedt J, Korhonen M, Jolkkonen J Tags: Behav Brain Res Source Type: research

A new method to assess weight-bearing distribution after central nervous system lesions in rats.
Abstract The aim of the present study is to assess the relevance of weight-bearing distribution (DWB) measurement in freely moving rats after stroke and thoracic spinal cord injuries. Animals were divided in 2 experiments: 1) The middle cerebral artery occlusion-reperfusion (MCAO-r) experiment containing the MCAO group in which focal brain ischemia was induced by transient MCA occlusion and 2) the thoracic hemisection experiment containing the TH group in which a spinal cord hemisection was performed at the T10 level. A Control and respective Sham groups were also included in each experiment. Not only the pressure...
Source: Behavioural Brain Research - November 4, 2013 Category: Neurology Authors: Pertici V, Pin-Barre C, Felix MS, Laurin J, Brisswalter J, Decherchi P Tags: Behav Brain Res Source Type: research

Adult hemiparkinsonian rats do not benefit from tactile stimulation.
Abstract Tactile stimulation (TS) applied to adult rats after cortical injury (medial frontal cortex aspiration or sensorimotor pial stripping stroke model) has been previously shown to ameliorate behavioral impairments and to improve morphological parameters like dendritic length of prefrontal cortical neurons (Gibb et al. Behav Brain Res 2010;214:102-7). The purpose of this study was to examine the effect of TS on healthy and hemiparkinsonian adult rats. Therefore, the animals received TS for 14 days and 15min three times daily. At different time points rats were tested in various behavioral tests (amphetamine-i...
Source: Behavioural Brain Research - December 13, 2013 Category: Neurology Authors: Effenberg A, Klein A, Gibb R, Carroll C, Baumgärtner W, Grothe C, Ratzka A Tags: Behav Brain Res Source Type: research

Illusory self-identification with an avatar reduces arousal responses to painful stimuli.
Abstract Looking at one's own body has been shown to induce analgesia. In the present work we investigated whether illusory self-identification with an avatar, as induced experimentally through visuo-tactile stimulation, modulates the response to painful stimuli. In 30 healthy volunteers, a robotic device was used to stroke the participants' back, while they viewed either the body of an avatar, a non-body object (control object), or a body avatar with scrambled body parts (control body). All were visually stimulated in either congruent or incongruent fashion with the participant's body. We collected physiological ...
Source: Behavioural Brain Research - January 8, 2014 Category: Neurology Authors: Romano D, Pfeiffer C, Maravita A, Blanke O Tags: Behav Brain Res Source Type: research

Bone Marrow Mononuclear Cell Transplantation Promotes Therapeutic Angiogenesis via Upregulation of the VEGF-VEGFR2 Signaling Pathway in a Rat Model of Vascular Dementia.
Abstract Bone marrow mononuclear cells (BMMNCs) are important for angiogenesis after stroke. We investigated the effects of BMMNCs on cognitive function, angiogenesis, and the vascular endothelial growth factor (VEGF)-VEGF receptor 2 (VEGFR2) signaling pathway in a rat model of vascular dementia. We transplanted BMMNCs into rats that had undergone permanent bilateral occlusion of the common carotid arteries (2VO) and observed their migration in vivo. On day 28, we assessed cognitive function with the Morris Water Maze test and examined vascular density and white matter damage within the corpus striatum by staining...
Source: Behavioural Brain Research - February 28, 2014 Category: Neurology Authors: Wang J, Fu X, Jiang C, Yu L, Wang M, Han W, Liu L, Wang J Tags: Behav Brain Res Source Type: research

The spontaneously hypertensive rat/Izm (SHR/Izm) shows attention deficit/hyperactivity disorder-like behaviors but without impulsive behavior: Therapeutic implications of low-dose methylphenidate.
In this study, ADHD-like behaviors in SHR/Izm were evaluated compared to Wistar rats. SHR/Izm showed high locomotor activity in the habituation phase in a novel environment, although locomotor activity in the initial exploratory phase was low. In a behavioral test for attention, spontaneous alternation behavior in the Y-maze test was impaired in SHR/Izm. However, impulsive behavior in the elevated-plus maze test, which is designed to detect anxiety-related behavior but also reflects impulsivity for novelty seeking, was comparable to Wistar rats. Hyperactivity and inattention, detected as ADHD-like behaviors in SHR/Izm, wer...
Source: Behavioural Brain Research - August 20, 2014 Category: Neurology Authors: Kishikawa Y, Kawahara Y, Yamada M, Kaneko F, Kawahara H, Nishi A Tags: Behav Brain Res Source Type: research

Objective Measures of Physical Activity, White Matter Integrity and Cognitive Status in Adults Over Age 80.
This study quantified the association between PA and WM integrity in adults over 80. The moderating effects of cardiometabolic conditions, physical functional limitations and WM hyperintensities were also examined, as they can affect PA and brain integrity. Fractional anisotropy (FA) from normal-appearing WM via diffusion tensor imaging and WM hyperintensities were obtained in 90 participants (mean age=87.4, 51.1% female, 55.6% white) with concurrent objective measures of steps, active energy expenditure (AEE in kcal), duration (minutes), and intensity (Metabolic equivalents, METs) via SenseWear Armband. Clinical adjudicat...
Source: Behavioural Brain Research - February 2, 2015 Category: Neurology Authors: Tian Q, Glynn NW, Erickson KI, Aizenstein HJ, Simonsick EM, Yaffe K, Harris TB, Kritchevsky SB, Boudreau RM, Newman AB, Lopez OL, Saxton J, Rosano C, for the Health ABC study Tags: Behav Brain Res Source Type: research

Complex assessment of distinct cognitive impairments following ouabain injection into the rat dorsoloateral striatum.
In conclusion, we developed an animal model of distinct cognitive impairments after focal brain injury that provides a convenient method to test the effectiveness of restorative therapies. PMID: 25845737 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - April 3, 2015 Category: Neurology Authors: Gornicka-Pawlak E, Janowski M, Jablonska A, Sypecka J, Domanska-Janik K Tags: Behav Brain Res Source Type: research