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Source: European Heart Journal

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Total 332 results found since Jan 2013.

Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial
ConclusionRoutine ingestion by hypertensive patients of ≥1 prescribed BP-lowering medications at bedtime, as opposed to upon waking, results in improved ABP control (significantly enhanced decrease in asleep BP and increased sleep-time relative BP decline, i.e. BP dipping) and, most importantly, markedly diminished occurrence of major CVD events.Trial registrationClinicalTrials.gov, number NCT00741585. 
Source: European Heart Journal - October 22, 2019 Category: Cardiology Source Type: research

Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
Conclusions  Larger early LDL-C reduction and more intensive statin therapy after MI were associated with a reduced hazard of all CV outcomes and all-cause mortality. This supports clinical trial data suggesting that earlier lowering of LDL-C after an MI confers the greatest benefit.
Source: European Heart Journal - December 24, 2020 Category: Cardiology Source Type: research

Gone with wind: a novel biodegradable occluder for percutaneous closure of patent foramen ovale
A 42-year-old man with a history of cryptogenic stroke and sequela free after medical therapy was found to have a patent foramen ovale (PFO) by transoesophageal echocardiography (TEE,Panel A, arrowhead indicates the PFO; Ao, aorta; LA, left atrium; RA, right atrium). Given a RoPE score of 7, he was referred for percutaneous PFO closure. A 24  mm × 24 mm fully biodegradable occluder (Pancy® occluder, ChiCTR1900024036,Panel E, arrowhead indicates marker) was delivered and deployed via a 10-Fr sheath (Mallow® delivery system) under florescent angiography and TEE (Panel B, arrowhead indicates the marker on occluder while ...
Source: European Heart Journal - October 2, 2020 Category: Cardiology Source Type: research

Vegetarians, fish, poultry, and meat-eaters: who has higher risk of cardiovascular disease incidence and mortality? A prospective study from UK Biobank
Conclusion  Eating fish rather than meat or poultry was associated with a lower risk of a range of adverse cardiovascular outcomes. Vegetarianism was only associated with a lower risk of CVD incidence.
Source: European Heart Journal - December 14, 2020 Category: Cardiology Source Type: research

Risk assessment and therapy decision in patients at low risk for stroke: CHA2DS2-VASc vs. CHADS2?
Source: European Heart Journal - January 14, 2013 Category: Cardiology Authors: Erdogan, O. Tags: EDITORIALS Source Type: research

N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS
Conclusion N-terminal pro-B-type natriuretic peptide predicts CVD events in men without clinical evidence of CHD, angina, or history of stroke, and appears related more strongly to the risk for fatal events. N-terminal pro-B-type natriuretic peptide also provides moderate risk discrimination, in excess of that provided by the measurement of C-reactive protein. Clinical trial registration WOSCOPS was carried out and completed prior to the requirement for clinical trial registration.
Source: European Heart Journal - February 7, 2013 Category: Cardiology Authors: Welsh, P., Doolin, O., Willeit, P., Packard, C., Macfarlane, P., Cobbe, S., Gudnason, V., Di Angelantonio, E., Ford, I., Sattar, N. Tags: Prevention/epidemiology Source Type: research

Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency
Conclusion Antihypertensive therapy reduces arterial and ventricular stiffness, enhances ventricular–arterial coupling, reduces cardiac work, and improves LV efficiency, systolic, and diastolic function. Attenuated responses in women and among obese subjects suggest that structure–function changes may be less reversible in these groups, possibly explaining their greater susceptibility to ultimately develop heart failure.
Source: European Heart Journal - March 1, 2013 Category: Cardiology Authors: Lam, C. S. P., Shah, A. M., Borlaug, B. A., Cheng, S., Verma, A., Izzo, J., Oparil, S., Aurigemma, G. P., Thomas, J. D., Pitt, B., Zile, M. R., Solomon, S. D. Tags: Hypertension Source Type: research

New oral anticoagulants in addition to single or dual antiplatelet therapy after an acute coronary syndrome: a systematic review and meta-analysis
Conclusion In patients with a recent acute coronary syndrome, the addition of a new oral anticoagulant to antiplatelet therapy results in a modest reduction in cardiovascular events but a substantial increase in bleeding, most pronounced when new oral anticoagulants are combined with dual antiplatelet therapy.
Source: European Heart Journal - June 7, 2013 Category: Cardiology Authors: Oldgren, J., Wallentin, L., Alexander, J. H., James, S., Jonelid, B., Steg, G., Sundstrom, J. Tags: Acute coronary syndromes Source Type: research

Effect of statin therapy on cardiovascular and renal outcomes in patients with chronic kidney disease: a systematic review and meta-analysis
Conclusion Statin therapy reduces the risk of major cardiovascular events in patients with chronic kidney disease including those receiving dialysis.
Source: European Heart Journal - June 21, 2013 Category: Cardiology Authors: Hou, W., Lv, J., Perkovic, V., Yang, L., Zhao, N., Jardine, M. J., Cass, A., Zhang, H., Wang, H. Tags: Prevention and epidemiology Source Type: research

Secondary prevention by stroke subtype: impact of the Korean experience
Source: European Heart Journal - September 14, 2013 Category: Cardiology Authors: Diener, H.-C. Tags: EDITORIALS Source Type: research

A new look at atrial fibrillation: lessons learned from drugs, pacing, and ablation therapies
Atrial fibrillation (AF) is the most common arrhythmia and among the leading causes of stroke and heart failure in Western populations. Despite the increasing size of clinical trials assessing the efficacy and safety of AF therapies, achieved outcomes have not always matched expectations. Considering that AF is a symptom of many possible underlying diseases, clinical research for this arrhythmia should take into account their respective pathophysiology. Accordingly, the definition of the study populations to be included should rely on the established as well as on the new classifications of AF and take advantage from a dif...
Source: European Heart Journal - September 14, 2013 Category: Cardiology Authors: Kappenberger, L. Tags: REVIEWS Source Type: research

The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk
Conclusions These findings suggest that CAD/MI-associated risk alleles play an aetiological role in different types of atherosclerotic disease.
Source: European Heart Journal - October 1, 2013 Category: Cardiology Authors: Tragante, V., Doevendans, P. A. F. M., Nathoe, H. M., van der Graaf, Y., Spiering, W., Algra, A., de Borst, G. J., de Bakker, P. I. W., Asselbergs, F. W., on behalf of the SMART study group Tags: Coronary artery disease Source Type: research

Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences
Conclusion A substantial proportion of people do not adhere adequately to cardiovascular medications, and the prevalence of suboptimal adherence is similar across all individual CVD medications. Absolute and relative risk assessments demonstrate that a considerable proportion of all CVD events (~9% in Europe) could be attributed to poor adherence to vascular medications alone, and that the level of optimal adherence confers a significant inverse association with subsequent adverse outcomes. Measures to enhance adherence to help maximize the potentials of effective cardiac therapies in the clinical setting are urgently required.
Source: European Heart Journal - October 7, 2013 Category: Cardiology Authors: Chowdhury, R., Khan, H., Heydon, E., Shroufi, A., Fahimi, S., Moore, C., Stricker, B., Mendis, S., Hofman, A., Mant, J., Franco, O. H. Tags: Prevention and epidemiology Source Type: research

Trends in age-specific coronary heart disease mortality in the European Union over three decades: 1980-2009
Conclusion There is limited evidence to support the hypothesis that CHD mortality rates in younger age groups in the member states of the EU have been more likely to plateau than in older age groups. There are, however, substantial and persistent inequalities between countries. It remains vitally important for the whole EU to monitor and work towards reducing preventable risk factors for CHD and other chronic conditions to promote wellbeing and equity across the region.
Source: European Heart Journal - October 14, 2013 Category: Cardiology Authors: Nichols, M., Townsend, N., Scarborough, P., Rayner, M. Tags: Coronary artery disease Source Type: research

Cardiovascular disease in Europe: epidemiological update
This overview provides a Europe-wide update on the current burden of cardiovascular disease, and specifically of coronary heart disease and stroke. Cardiovascular disease continues to cause a large proportion of deaths and disability in Europe, and places a substantial burden on the health care systems and economies of Europe. The overall picture, and the distribution of the burden, continues to evolve in a developing Europe. There have been major improvements in recent years on many measures of cardiovascular disease; however, these improvements have not been universal, and substantial inequalities persist.
Source: European Heart Journal - October 14, 2013 Category: Cardiology Authors: Nichols, M., Townsend, N., Scarborough, P., Rayner, M. Tags: FASTTRACK SPECIAL ARTICLE Source Type: research