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Source: European Heart Journal

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Total 332 results found since Jan 2013.

Updated European Heart Rhythm Association practical guide on the use of non-vitamin-K antagonist anticoagulants in patients with non-valvular atrial fibrillation: Executive summary
AbstractIn 2013, the European Heart Rhythm Association (EHRA) published a Practical Guide on the use of non-VKA oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) (Heidbuchel H, Verhamme P, Alings M, Antz M, Hacke W, Oldgren J, Sinnaeve P, Camm AJ, Kirchhof P, European Heart Rhythm A. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation.Europace 2013;15:625 –651; Heidbuchel H, Verhamme P, Alings M, Antz M, Hacke W, Oldgren J, Sinnaeve P, Camm AJ, Kirchhof P. EHRA practical guide on the use of new oral anticoagulants in...
Source: European Heart Journal - June 9, 2016 Category: Cardiology Source Type: research

Low-density lipoprotein cholesterol targeting with pitavastatin + ezetimibe for patients with acute coronary syndrome and dyslipidaemia: the HIJ-PROPER study, a prospective, open-label, randomized trial
ConclusionAlthough intensive lowering with standard pitavastatin plus ezetimibe showed no more cardiovascular benefit than standard pitavastatin monotherapy in ACS patients with dyslipidaemia, statin plus ezetimibe may be more effective than statin monotherapy in patients with higher cholesterol absorption; further confirmation is needed.Trial NoUMIN000002742, registered as an International Standard Randomized Controlled Trial.
Source: European Heart Journal - April 18, 2017 Category: Cardiology Source Type: research

Final 5-year clinical and echocardiographic results for treatment of severe aortic stenosis with a self-expanding bioprosthesis from the ADVANCE Study
ConclusionFive-year results in real-world, elderly, high-risk patients undergoing TAVI with a self-expanding bioprosthesis provided evidence for continued valve durability with low rates of reinterventions and haemodynamic valve dysfunction.Trial registrationClinicalTrials.gov, NCT01074658.
Source: European Heart Journal - June 13, 2017 Category: Cardiology Source Type: research

Finding ideal blood pressure targets in ischaemic stroke: prospective insight or retrospective guesswork?
This editorial refers to ‘Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke’†, by S. Bangaloreet al., on page2827.
Source: European Heart Journal - July 31, 2017 Category: Cardiology Source Type: research

Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial
ConclusionIn patients with stable coronary heart disease, higher visit-to-visit variabilities of both systolic and diastolic BP are strong predictors of increased risk of cardiovascular events, independently of mean BP.
Source: European Heart Journal - May 27, 2017 Category: Cardiology Source Type: research

Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice
ConclusionWe established a novel and unique aircraft noise stress model with increased blood pressure and vascular dysfunction associated with oxidative stress. This animal model enables future studies of molecular mechanisms, mitigation strategies, and pharmacological interventions to protect from noise-induced vascular damage.
Source: European Heart Journal - February 17, 2017 Category: Cardiology Source Type: research

Uncommon cause of dyspnoea after percutaneous closure of the left atrial appendage
A 69-year-old female with persistent atrial fibrillation and history of recurrent strokes presented with progressive shortness of breath. Three years ago, percutaneous closure of the left atrial appendage (LAA) for stroke prophylaxis was performed using an Amplatzer Amulet® device (St. Jude Medical, MN, USA).
Source: European Heart Journal - August 1, 2017 Category: Cardiology Source Type: research

Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
ConclusionsTransthyretin cardiac amyloidosis is prevalent in 16% of patients with severe calcific AS undergoing TAVR and is associated with a severe AS phenotype of low-flow low-gradient with mildly reduced ejection fraction. Average tissue Doppler mitral annular S ’ of <  6 cm/s may be a sensitive measure that should prompt a confirmatory99mTc-PYP scan and subsequent testing for ATTR-CA. Prospective assessment of outcomes after TAVR is needed in patients with and without ATTR-CA.
Source: European Heart Journal - August 1, 2017 Category: Cardiology Source Type: research

Improved outcomes in patients with ST-elevation myocardial infarction during the last 20  years are related to implementation of evidence-based treatments: experiences from the SWEDEHEART registry 1995–2014
ConclusionGradual implementation of new and established evidence-based treatments in STEMI patients during the last 20  years has been associated with prolonged survival and lower risk of recurrent ischaemic events, although a plateauing is seen since around 2008.
Source: European Heart Journal - August 29, 2017 Category: Cardiology Source Type: research

Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study
ConclusionA switched DAPT is superior to an unchanged DAPT strategy to prevent bleeding complications without increase in ischaemic events following ACS.
Source: European Heart Journal - May 16, 2017 Category: Cardiology Source Type: research

A Swiss National Strategy for 2017 –2024
A Swiss National Strategy for Cardiovascular disease, Stroke, and Diabetes for the next 7  years has been produced through a joint initiative of 26 National Cardiovascular Societies and the Swiss Heart Foundation 
Source: European Heart Journal - November 7, 2017 Category: Cardiology Source Type: research

Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study
ConclusionAt one year, clinical outcomes with the SYNTAX-II strategy were associated with improved clinical results compared to the PCI performed in comparable patients from the original SYNTAX-I trial. Longer term follow-up is awaited and a randomized clinical trial with contemporary CABG is warranted.ClinicalTrials.gov IdentifierNCT02015832
Source: European Heart Journal - August 26, 2017 Category: Cardiology Source Type: research

Safety and efficacy of a repositionable and fully retrievable aortic valve used in routine clinical practice: the RESPOND Study
ConclusionThe results of RESPOND confirm the safety and efficacy of TAVI with the Lotus Valve in routine clinical practice.Trial registrationClinicalTrials.gov #NCT 02031302.
Source: European Heart Journal - June 22, 2017 Category: Cardiology Source Type: research

Foreign body granuloma as an unexpected long-term finding after percutaneous closure of a patent foramen ovale
A 67-year-old man was referred to our hospital for catheter ablation of atrial fibrillation. Eight years earlier, prior to diagnosis of atrial fibrillation, the patient suffered an ischaemic stroke. A patent foramen ovale (PFO) was diagnosed and the patient underwent percutaneous PFO closure by implantation of a Premere device (20  mm, St. Jude Medical). One month ago, the patient had another middle-cerebral artery infarction, which was considered cardioembolic due to insufficient anticoagulation. However, transthoracic echocardiography (TTE) obtained on current admission demonstrated a suspicious mass in the left atrium...
Source: European Heart Journal - March 24, 2017 Category: Cardiology Source Type: research

Cholesterol variability: a marker for increased risk or a risk factor?
This editorial refers to ‘Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study’†, by M.K. Kimet al., on page3560.
Source: European Heart Journal - November 13, 2017 Category: Cardiology Source Type: research