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Source: European Heart Journal

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Total 332 results found since Jan 2013.

Supracardiac atherosclerosis in embolic stroke of undetermined source: the underestimated source
AbstractThe term ‘embolic stroke of undetermined source’ (ESUS) is used to describe patients with a non-lacunar ischaemic stroke without any identified embolic source from the heart or the arteries supplying the ischaemic territory, or any other apparent cause. When the ESUS concept was introduced, covert atrial fibrillation was conceived to be the main underlying cause in the majority of ESUS patients. Another important embolic source in ESUS is the atherosclerotic plaque in the carotid, vertebrobasilar, and intracranial arteries, or the aortic arch—collectively described as supracardiac atherosclerosis . There is e...
Source: European Heart Journal - April 16, 2020 Category: Cardiology Source Type: research

Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death
Conclusions Elastin fragmentation plays a key role in plaque destabilization and rupture. ApoE–/–Fbn1C1039G+/– mice represent a unique model of acute plaque rupture with human-like complications.
Source: European Heart Journal - May 1, 2015 Category: Cardiology Authors: Van der Donckt, C., Van Herck, J. L., Schrijvers, D. M., Vanhoutte, G., Verhoye, M., Blockx, I., Van Der Linden, A., Bauters, D., Lijnen, H. R., Sluimer, J. C., Roth, L., Van Hove, C. E., Fransen, P., Knaapen, M. W., Hervent, A.-S., De Keulenaer, G. W., B Tags: BASIC SCIENCE Source Type: research

Cardiac diagnostic work-up of ischaemic stroke
AbstractCardioembolic sources account for 20 –30% of ischaemic strokes and are important to identify considering their prognostic and therapeutic implications. During the past years, new developments have been made in the cardiac diagnostic evaluation and management of patients with ischaemic stroke, especially regarding strokes of unknown a etiology. These recent advances have had a major impact on our understanding of embolic strokes, their diagnostic work-up, and clinical management. Herein, we propose a cardiac diagnostic work-up scheme for patients with ischaemic stroke from definite cardioembolic sources and emboli...
Source: European Heart Journal - May 21, 2018 Category: Cardiology Source Type: research

Stroke in cardiovascular interventions
<span class="paragraphSection"><strong>The ESC Stroke Council proposes that neurological deficits resulting from cardiovascular interventions should be classified and documented</strong>  </span>
Source: European Heart Journal - May 1, 2017 Category: Cardiology Source Type: research

Stroke management by cardiologists
Catheter-based acute ischaemic stroke management by cardiologists;promises andpremises 
Source: European Heart Journal - August 14, 2017 Category: Cardiology Source Type: research

Streamlining primary and secondary care management pathways for stroke prevention in atrial fibrillation
Improving anticoagulation rates and stroke outcomes by collaborative working and application of the simple ‘Birmingham 3-step’ approach
Source: European Heart Journal - October 21, 2017 Category: Cardiology Source Type: research

Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke
ConclusionPCSK9 genetic variants that confer life-long lower PCSK9 and LDL-C levels appear to have significantly weaker, if any, associations with risk of IS than with risk of CHD. By contrast, similar proportional reductions in risks of IS and CHD have been observed in randomized trials of therapeutic PCSK9-inhibition. These findings have implications for our understanding of when Mendelian randomization can be relied upon to predict the effects of therapeutic interventions.
Source: European Heart Journal - July 17, 2017 Category: Cardiology Source Type: research

Impact of low stroke volume on mortality in patients with severe aortic stenosis and preserved left ventricular ejection fraction
ConclusionLow flow defined as SVi  <  30 mL/m2 or SV  <  55 mL is an important outcome predictor in severe AS with preserved LVEF under medical and surgical management. Further studies are needed to prospectively test these values for risk stratification and decision making.
Source: European Heart Journal - March 13, 2018 Category: Cardiology Source Type: research

Diabetes and ischaemic stroke: a deadly association
This editorial refers to ‘Diabetes and long-term outcomes of ischaemic stroke: findings from Get With The Guidelines-Stroke’††, by J.B. Echouffo-Tcheuguiet al., on page2376.
Source: European Heart Journal - February 9, 2018 Category: Cardiology Source Type: research

Corrigendum to: Risk stratification for stroke in atrial fibrillation: incorporating neurologists in the comprehensive management
[Eur Heart J 2019;40:3058 –3059].
Source: European Heart Journal - August 19, 2019 Category: Cardiology Source Type: research

Risk stratification for stroke in atrial fibrillation: incorporating neurologists in the comprehensive management
This commentary refers to ‘Risk stratification for stroke in atrial fibrillation: a critique’, by A.M. Killuet al., 2019;40:1294 –1302.
Source: European Heart Journal - July 13, 2019 Category: Cardiology Source Type: research

Response to: Risk stratification for stroke in atrial fibrillation: incorporating neurologists in the comprehensive management
This commentary refers to ‘Risk stratification for stroke in atrial fibrillation: incorporating neurologists in the comprehensive management’†, by H.-F. Liet al., 2019;40:3058 –3059.
Source: European Heart Journal - July 13, 2019 Category: Cardiology Source Type: research

Validation of risk scores for ischaemic stroke in atrial fibrillation across the spectrum of kidney function
Conclusion  In the most clinically relevant stages of CKD, predictive performance of the majority of risk scores was poor, increasing the risk of misclassification and thus of over- or undertreatment. The Modified CHADS2 score performed good and consistently across all kidney function strata, and should therefore be preferred for risk estimation in AF patients.
Source: European Heart Journal - March 26, 2021 Category: Cardiology Source Type: research

Renal function and outcomes in anticoagulated patients with non-valvular atrial fibrillation: the AMADEUS trial
Conclusion Renal impairment (CrCl <60 mL/min) doubles the risk of stroke and increased the risk of major bleeding by almost 60% in anticoagulated patients with AF. Renal impairment was additive to stroke risk prediction scores based on a significant NRI, but no significant improvement in discrimination ability (based on c-indexes) for CHA2DS2VASc or CHADS2 was observed.
Source: European Heart Journal - December 7, 2013 Category: Cardiology Authors: Apostolakis, S., Guo, Y., Lane, D. A., Buller, H., Lip, G. Y. H. Tags: Atrial fibrillation Source Type: research

Initiation of warfarin in patients with atrial fibrillation: early effects on ischaemic strokes
Conclusion Patients initiating warfarin may be at an increased risk of stroke during the first 30 days of treatment, supporting the biological plausibility of a transient hypercoagulable state at the start of the treatment, although additional studies are needed to confirm these findings.
Source: European Heart Journal - July 21, 2014 Category: Cardiology Authors: Azoulay, L., Dell'Aniello, S., Simon, T. A., Renoux, C., Suissa, S. Tags: Atrial fibrillation Source Type: research