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Molecules, Vol. 28, Pages 2598: Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia
This study explored the effects of Gas and HBA on cognitive dysfunction in VD and their possible molecular mechanisms. The VD model was established by bilateral common carotid artery ligation (2-vessel occlusion, 2-VO) combined with an intraperitoneal injection of sodium nitroprusside solution. One week after modeling, Gas (25 and 50 mg/kg, i.g.) and HBA (25 and 50 mg/kg, i.g.) were administered orally for four weeks, and the efficacy was evaluated. A Morris water maze test and passive avoidance test were used to observe their cognitive function, and H&E staining and Nissl staining were used to observe the neur...
Source: Molecules - March 13, 2023 Category: Chemistry Authors: Sha Wu Rong Huang Ruiqin Zhang Chuang Xiao Lueli Wang Min Luo Na Song Jie Zhang Fang Yang Xuan Liu Weimin Yang Tags: Article Source Type: research
