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Development of rapid and effective risk prediction models for stroke in the Chinese population: a cross-sectional study
Conclusion The five machine learning models all had good predictive and discriminatory performance for stroke. The performance of RF and XGBoost was slightly better than that of LR, which was easier to interpret and less prone to overfitting. This work provides a rapid and accurate tool for stroke risk assessment, which can help to improve the efficiency of stroke screening medical services and the management of high-risk groups.
Source: BMJ Open - March 1, 2023 Category: General Medicine Authors: Qiu, Y., Cheng, S., Wu, Y., Yan, W., Hu, S., Chen, Y., Xu, Y., Chen, X., Yang, J., Chen, X., Zheng, H. Tags: Open access, Public health Source Type: research

A nurse-led health coaching intervention for stroke survivors and their family caregivers in hospital to home transition care in Chongqing, China: a study protocol for a randomized controlled trial
Hospital to home transition care is a most stressful period for stroke survivors and their caregivers to learn self-management of stroke-related health conditions and to engage in rehabilitation. Health coachi...
Source: Trials - March 4, 2020 Category: General Medicine Authors: Shuanglan Lin, Lily Dongxia Xiao and Diane Chamberlain Tags: Study protocol Source Type: research

Detection of Asymptomatic Carotid Artery Stenosis in High-Risk Individuals of Stroke Using a Machine-Learning Algorithm
Publication date: December 2020Source: Chinese Medical Sciences Journal, Volume 35, Issue 4Author(s): Junxiong Yin, Cheng Yu, Lixia Wei, Chuanyong Yu, Hongxing Liu, Mingyang Du, Feng Sun, Chongjun Wang, Xiaoshan Wang
Source: Chinese Medical Sciences Journal - January 12, 2021 Category: General Medicine Source Type: research

Dl-3-n-butylphthalide alleviates cognitive impairment in amyloid precursor protein/presenilin 1 transgenic mice by regulating the striatal-enriched protein tyrosine phosphatase/ERK/cAMP-response element-binding protein signaling pathway
In conclusion, the present study provided evidence to suggest that the new drug NBP improved amyloid-induced learning and memory deficits, likely through the regulation of the STEP/ERK/CREB pathway. The results revealed that NBP, as a multi-target drug, may exert a neuroprotective effect. Therefore, NBP may serve as an effective treatment for AD.PMID:35350668 | PMC:PMC8943801 | DOI:10.3892/etm.2022.11248
Source: Experimental and Therapeutic Medicine - March 30, 2022 Category: General Medicine Authors: Yan Zhao Wen-Qiang Yang Lu Yu Jing Yang Hai-Rong Zhu Lin Zhang Source Type: research