• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Small vessel disease burden predicts functional outcomes in patients with acute ischemic stroke using machine learning
CONCLUSIONS: Our results revealed that different SVD markers had distinct prognostic weights in AIS patients, and SVD burden alone may accurately predict the SVO-AIS patients' prognosis.PMID:36650639 | DOI:10.1111/cns.14071
Source: CNS Neuroscience and Therapeutics - January 17, 2023 Category: Neuroscience Authors: Xueyang Wang Jinhao Lyu Zhihua Meng Xiaoyan Wu Wen Chen Guohua Wang Qingliang Niu Xin Li Yitong Bian Dan Han Weiting Guo Shuai Yang Xiangbing Bian Yina Lan Liuxian Wang Qi Duan Tingyang Zhang Caohui Duan Chenglin Tian Ling Chen Xin Lou MR-STARS Investigat Source Type: research

Recent highlights in periopeative neurological disorders, from bench to bedside
CNS Neurosci Ther. 2022 Feb 11. doi: 10.1111/cns.13771. Online ahead of print.ABSTRACTPerioperative neurological disorders are important causes of postoperative disability and even perioperative death, bringing a huge challenge to the vulnerable and increasing aging population. Perioperative neurological disorders usually contain ischemic stroke, hemorrhagic stroke, and neurocognitive disorders during the perioperative period. Although a few prevention and treatment strategies have been developed for each disorder, there is still a lack of effective treatments and the underlying mechanisms are far from well-understood. Thi...
Source: CNS Neuroscience and Therapeutics - February 11, 2022 Category: Neuroscience Authors: Yunlu Guo Peiying Li Source Type: research

Progranulin promotes hippocampal neurogenesis and alleviates anxiety-like behavior and cognitive impairment in adult mice subjected to cerebral ischemia
CONCLUSIONS: Progranulin alleviates ischemia-induced anxiety-like behavior and spatial learning and memory impairment in mice, probably via stimulation of hippocampal neurogenesis mediated by activation of MAPK/ERK and PI3K/Akt pathways. PGRN might be a promising candidate for coping with ischemic stroke-induced mood and cognitive impairment in clinic.PMID:35146924 | DOI:10.1111/cns.13810
Source: CNS Neuroscience and Therapeutics - February 11, 2022 Category: Neuroscience Authors: Siqi Sun Jinlong Zhou Zhongqi Li Yuzi Wu Hao Wang Qi Zheng Frank Adu-Nti Juan Fan Yingfang Tian Source Type: research