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Pharmacological Enhancement of Stroke Recovery
AbstractPurpose of ReviewThis review aims to discuss the recent literature relating to drugs for stroke recovery and to identify some of the challenges in conducting translational research for stroke recovery.Recent FindingsAdvances in our understanding of neural repair mechanisms in pre-clinical stroke models have provided insights into potential targets for drugs that enhance the repair/recovery process. Few drugs that act on serotonergic and dopaminergic systems have been tested in humans with mixed results. The FOCUS trial, a phase III study of early administration of fluoxetine for stroke recovery, failed to replicate...
Source: Current Neurology and Neuroscience Reports - May 29, 2019 Category: Neuroscience Source Type: research

The Allure of Big Data to Improve Stroke Outcomes: Review of Current Literature
AbstractPurpose of ReviewTo critically appraise literature on recent advances and methods using “big data” to evaluate stroke outcomes and associated factors.Recent FindingsRecent big data studies provided new evidence on the incidence of stroke outcomes, and important emerging predictors of these outcomes. Main highlights included the identification of COVID-19 infection and exposure to a low-dose particulate matter as emerging predictors of mortality post-stroke. Demographic (age, sex) and geographical (rural vs. urban) disparities in outcomes were also identified. There was a surge in methodological (e.g., machine l...
Source: Current Neurology and Neuroscience Reports - March 11, 2022 Category: Neuroscience Source Type: research

Rapid Response EEG: Current State and Future Directions
AbstractPurpose of ReviewTo critically appraise the literature on the application, methods, and advances in emergency electroencephalography (EEG).Recent FindingsThe development of rapid EEG (rEEG) technologies and other reduced montage approaches, along with advances in machine learning over the past decade, has increased the rate and access to EEG acquisition. These achievements have made EEG in the emergency setting a practical diagnostic technique for detecting seizures, suspected nonconvulsive status epilepticus (NCSE), altered mental status, stroke, and in the setting of sedation.SummaryGrowing evidence supports usin...
Source: Current Neurology and Neuroscience Reports - November 25, 2022 Category: Neuroscience Source Type: research