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A Machine Learning Approach for Classifying Ischemic Stroke Onset Time From Imaging
Current clinical practice relies on clinical history to determine the time since stroke (TSS) onset. Imaging-based determination of acute stroke onset time could provide critical information to clinicians in deciding stroke treatment options, such as thrombolysis. The patients with unknown or unwitnessed TSS are usually excluded from thrombolysis, even if their symptoms began within the therapeutic window. In this paper, we demonstrate a machine learning approach for TSS classification using routinely acquired imaging sequences. We develop imaging features from the magnetic resonance (MR) images and train machine learning ...
Source: IEE Transactions on Medical Imaging - June 30, 2019 Category: Biomedical Engineering Source Type: research

Determining Clinically-Viable Biomarkers for Ischaemic Stroke Through a Mechanistic and Machine Learning Approach
Ann Biomed Eng. 2022 Apr 1. doi: 10.1007/s10439-022-02956-7. Online ahead of print.ABSTRACTAssessment of distal cerebral perfusion after ischaemic stroke is currently only possible through expensive and time-consuming imaging procedures which require the injection of a contrast medium. Alternative approaches that could indicate earlier the impact of blood flow occlusion on distal cerebral perfusion are currently lacking. The aim of this study was to identify novel biomarkers suitable for clinical implementation using less invasive diagnostic techniques such as Transcranial Doppler (TCD). We used 1D modelling to simulate pr...
Source: Annals of Biomedical Engineering - April 2, 2022 Category: Biomedical Engineering Authors: Ivan Benemerito Ana Paula Narata Andrew Narracott Alberto Marzo Source Type: research

Prediction of Hemorrhagic Transformation Severity in Acute Stroke From Source Perfusion MRI
Conclusion: The key contribution of our framework formalize HT prediction as a machine learning problem. Specifically, the model learns to extract imaging markers of HT directly from source PWI images rather than from pre-established metrics. Significance: Predictions visualized in terms of spatial likelihood of HT in various territories of the brain were evaluated against follow-up gradient recalled echo and provide novel insights for neurointerventionalists prior to endovascular therapy.
Source: IEEE Transactions on Biomedical Engineering - August 21, 2018 Category: Biomedical Engineering Source Type: research

C2MA-Net: Cross-Modal Cross-Attention Network for Acute Ischemic Stroke Lesion Segmentation Based on CT Perfusion Scans
Conclusion: This study demonstrates advantages of applying C2MA-network to segment AIS lesions, which yields promising segmentation accuracy, and achieves semantic decoupling by processing different parameter modalities separately. Significance: Proving the potential of cross-modal interactions in attention to assist identifying new imaging biomarkers for more accurately predicting AIS prognosis in future studies.
Source: IEEE Transactions on Biomedical Engineering - December 24, 2021 Category: Biomedical Engineering Source Type: research

Stacked Bidirectional Convolutional LSTMs for Deriving 3D Non-Contrast CT From Spatiotemporal 4D CT
The imaging workup in acute stroke can be simplified by deriving non-contrast CT (NCCT) from CT perfusion (CTP) images. This results in reduced workup time and radiation dose. To achieve this, we present a stacked bidirectional convolutional LSTM (C-LSTM) network to predict 3D volumes from 4D spatiotemporal data. Several parameterizations of the C-LSTM network were trained on a set of 17 CTP-NCCT pairs to learn to derive a NCCT from CTP and were subsequently quantitatively evaluated on a separate cohort of 16 cases. The results show that the C-LSTM network clearly outperforms the baseline and competitive convolutional neur...
Source: IEE Transactions on Medical Imaging - March 31, 2020 Category: Biomedical Engineering Source Type: research