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Lithium chloride promotes neural functional recovery after local cerebral ischemia injury in rats through Wnt signaling pathway activation
Folia Morphol (Warsz). 2022 Aug 2. doi: 10.5603/FM.a2022.0068. Online ahead of print.ABSTRACTLithium chloride (LiCl) has a significant neuroprotective effect in cerebral ischemia. However, to date, there is a paucity of evidence on the role of LiCl in neural restoration after brain ischemia and the signaling pathways involved remain unclear. Therefore, to address this gap, the middle cerebral artery occlusion (MCAO) rat model was used to simulate human ischemia stroke. Male SD rats were given MCAO for 90 min followed by reperfusion, and Dickkopf-1(DKK1, 5.0 μg/kg) was administered half an hour before MCAO. Rats were then ...
Source: Folia Morphologica - August 2, 2022 Category: Anatomy Authors: Z Junde L Tingting Z Lu C Shan Y Dan Source Type: research

The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3 β inhibition in intracerebral hemorrhage rats.
In this study, Male Sprague-Dawley rats, subjected to intrastriatal blood infusion, were treated with lithium chloride and underwent neurobehavioral test for equivalent injury severity and neurological functional deficits, Morris water maze test for cognitive impairment, high performance liquid chromatography analysis for excitotoxic index determination, immunohistochemistry analysis for neuronal apoptosis, and Western blot analysis for glycogen synthase kinase-3β activity. Our results showed lithium chloride inhibited glycogen synthase kinase-3β activation, which on one hand, suppressed downstream CRMP-2/NR2B, thus dimi...
Source: European Journal of Pharmacology - October 15, 2018 Category: Drugs & Pharmacology Authors: Liu Z, Li R, Jiang C, Zhao S, Li W, Tang X Tags: Eur J Pharmacol Source Type: research

Transcranial Direct Current Stimulation Use in Warfighting: Benefits, Risks, and Future Prospects
Conclusion The aim of this paper was to examine whether military tDCS use can be efficacious and ethical in military settings. Our assessment is that tDCS offers a number of cognitive, motor, and perceptual enhancement opportunities which could provide value in military situations like training and operations. There is potential scope for use in a number of key areas that directly affect practical battlefield advantage and survivability, such as deceptive capabilities, risk-taking, threat detection, perception, and physiological improvement. Additionally, tDCS has the potential to improve command and control decision maki...
Source: Frontiers in Human Neuroscience - April 17, 2019 Category: Neuroscience Source Type: research

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