• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Alpha-Asarone Ameliorates Neurological Dysfunction of Subarachnoid Hemorrhagic Rats in Both Acute and Recovery Phases via Regulating the CaMKII-Dependent Pathways
AbstractEarly brain injury (EBI) is the leading cause of poor prognosis for patients suffering from subarachnoid hemorrhage (SAH), particularly learning and memory deficits in the repair phase. A recent report has involved calcium/calmodulin-dependent protein kinase II (CaMKII) in the pathophysiological process underlying SAH-induced EBI. Alpha-asarone (ASA), a major compound isolated from the Chinese medicinal herbAcorus tatarinowii Schott, was proven to reduce secondary brain injury by decreasing CaMKII over-phosphorylation in rats ’ model of intracerebral hemorrhage in our previous report. However, the effect of ASA o...
Source: Translational Stroke Research - February 13, 2023 Category: Neurology Source Type: research

Edaravone Dexborneol Alleviates Neuroinflammation by Reducing Neuroglial Cell Proliferation and Suppresses Neuronal Apoptosis/Autophagy in Vascular Dementia Rats
In this study, we established the VD model of rats by bilateral carotid artery occlusion to explore the neuroprotective effect of EDB and its mechanism. Morris Water Maze test was applied to assess the cognitive function of rats. H&E and TUNEL staining were applied to observe the cellular structure of the hippocampus. Immunofluorescence labeling was used to observe the proliferation of astrocytes and microglia. ELISA was applied to examine the levels of TNF-α, IL-1β and IL-6, and RT-PCR was applied to examine their mRNA expression levels. Western blotting was applied to examine apoptosis-related proteins (Bax, Bcl-2,...
Source: Neurochemical Research - June 20, 2023 Category: Neuroscience Authors: Jiawei Zhang Yining Xiao Hongna Liu Lili Xu Xing Guo Yaran Gao Meixi Li Jing Xu Qianqian Qi Peiyuan Lv Source Type: research

Streamlined Carotid Artery Calcification Labeling For Cta Scans
Introduction: We require vast amounts of manually labeled calcifications to train advanced machine learning classifiers for carotid artery plaque detection and phenotyping high-risk calcifications for ischemic stroke patients. We developed CTOOL, a web-based software for streamlined calcium labeling with minimal user interaction.
Source: Journal of Cardiovascular Computed Tomography - July 1, 2023 Category: Radiology Authors: J. Kim, N. Arnett, J. Kotler, D. Shah, B. Cucchiara, J. Song, D. Haehn Source Type: research

Pages: 1  2  3  4