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Continuous and not continuous 2-week treadmill training enhances the performance in the passive avoidance test in ischemic gerbils
This study aims to investigate the frequency and total duration effects of the 2-week treadmill training after experimental ischemic stroke in the passive avoidance test. We performed bilateral occlusion of common external carotid arteries, for five minutes, in Mongolian gerbils. The training groups were: continuous training for twelve consecutive days or not continuous training for six non-consecutive days. The groups remained in the treadmill for 15min, with the speed set at 10m/min, and the training started 24h after the stroke. In the Shuttle Box, each animal had ten trials during the Learning Session (LS), which occur...
Source: Neuroscience Letters - December 16, 2017 Category: Neuroscience Source Type: research

Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats
Publication date: 23 March 2016 Source:Neuroscience Letters, Volume 617 Author(s): Yaning Liu, Shangwu Wang, Shijian Luo, Zhendong Li, Fengyin Liang, Yanan Zhu, Zhong Pei, Ruxun Huang Glial cell line-derived neurotrophic factor (GDNF) is a potential therapeutic protein on a variety of central nervous system diseases including ischemic stroke. However, GDNF is a large molecule that cannot cross the blood–brain barrier (BBB), which is still intact in the early hours after stroke when neural rescue is possible. PEP-1 protein transduction domain can deliver protein cargo across the cell membrane and the BBB. In the...
Source: Neuroscience Letters - February 20, 2016 Category: Neuroscience Source Type: research