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Continuous and not continuous 2-week treadmill training enhances the performance in the passive avoidance test in ischemic gerbils
This study aims to investigate the frequency and total duration effects of the 2-week treadmill training after experimental ischemic stroke in the passive avoidance test. We performed bilateral occlusion of common external carotid arteries, for five minutes, in Mongolian gerbils. The training groups were: continuous training for twelve consecutive days or not continuous training for six non-consecutive days. The groups remained in the treadmill for 15min, with the speed set at 10m/min, and the training started 24h after the stroke. In the Shuttle Box, each animal had ten trials during the Learning Session (LS), which occur...
Source: Neuroscience Letters - December 16, 2017 Category: Neuroscience Source Type: research

Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats
Publication date: 23 March 2016 Source:Neuroscience Letters, Volume 617 Author(s): Yaning Liu, Shangwu Wang, Shijian Luo, Zhendong Li, Fengyin Liang, Yanan Zhu, Zhong Pei, Ruxun Huang Glial cell line-derived neurotrophic factor (GDNF) is a potential therapeutic protein on a variety of central nervous system diseases including ischemic stroke. However, GDNF is a large molecule that cannot cross the blood–brain barrier (BBB), which is still intact in the early hours after stroke when neural rescue is possible. PEP-1 protein transduction domain can deliver protein cargo across the cell membrane and the BBB. In the...
Source: Neuroscience Letters - February 20, 2016 Category: Neuroscience Source Type: research

Experiencing a reaching task passively with one arm while adapting to a visuomotor rotation with the other can lead to substantial transfer of motor learning across the arms
Publication date: 18 January 2017 Source:Neuroscience Letters, Volume 638 Author(s): Shancheng Bao, Yuming Lei, Jinsung Wang The extent of transfer following visuomotor adaptation across the arms is typically limited as compared to that within the same arm. However, we have demonstrated that interlimb transfer can occur nearly completely if one arm performs reaching movements associated with a desired trajectory repeatedly and actively during an initial training session in which the other arm adapts to a novel visuomotor adaptation. Based on that finding, we argued that the absence of instances associated with specific mo...
Source: Neuroscience Letters - December 16, 2016 Category: Neuroscience Source Type: research

Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus
Publication date: Available online 1 November 2018Source: Neuroscience LettersAuthor(s): Marharyta Semenikhina, Ruslan Bogovyk, Mykhailo Fedoriuk, Oksana Nikolaienko, Lina T. AlKury, Alina Savotchenko, Oleg Krishtal, Elena IsaevaAbstractThe blood-brain barrier (BBB) is a unique structure that controls substances exchange between the systemic circulation and the brain. Disruption of its integrity contributes to the development and progression of a variety of brain disorders including stroke, epilepsy and neurodegenerative diseases. It was shown that intracerebral thrombin level substantially increases following status epile...
Source: Neuroscience Letters - November 2, 2018 Category: Neuroscience Source Type: research

Multimodal magnetic resonance imaging correlates of motor outcome after stroke using machine learning
Publication date: Available online 6 November 2020Source: Neuroscience LettersAuthor(s): Hea Eun Yang, Sunghyon Kyeong, Hyunkoo Kang, Dae Hyun Kim
Source: Neuroscience Letters - November 8, 2020 Category: Neuroscience Source Type: research