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Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation.
CONCLUSIONS: -By identifying known drugs as potential therapeutics for CCM, we have decreased the time, cost, and risk of bringing treatments to patients. Each drug also prompts additional exploration of biomarkers of CCM disease. We further suggest that the structure-function screening platform presented here may be adapted and scaled to facilitate drug discovery for diverse loss-of-function genetic vascular disease. PMID: 25486933 [PubMed - as supplied by publisher]
Source: Circulation - December 8, 2014 Category: Cardiology Authors: Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY Tags: Circulation Source Type: research