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PCSK9 Variants, LDL-Cholesterol, and Neurocognitive Impairment: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
Conclusions -These results suggest life-long exposure to low PCSK9 levels and cumulative exposure to lower LDL-C are not associated with neurocognitive effects in African Americans. PMID: 29146683 [PubMed - as supplied by publisher]
Source: Circulation - November 16, 2017 Category: Cardiology Authors: Mefford MT, Rosenson RS, Cushman M, Farkouh ME, McClure LA, Wadley VG, Irvin MR, Bittner VA, Safford MM, Somaratne R, Monda KL, Muntner P, Levitan EB Tags: Circulation Source Type: research

Medical Nutrition Education, Training, and Competencies to Advance Guideline-Based Diet Counseling by Physicians: A Science Advisory From the American Heart Association.
lar and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Stroke Council Abstract Growing scientific evidence of the benefits of heart-healthy dietary patterns and of the massive public health and economic burdens attributed to obesity and poor diet quality have triggered national calls to increase diet counseling in outpatients with atherosclerotic cardiovascular disease or risk factors. However, despite evidence that physicians are willing to undertake this task and are viewed as credible sources of diet information, they engage patients in diet counseling at less than desirable rates and...
Source: Circulation - April 30, 2018 Category: Cardiology Authors: Aspry KE, Van Horn L, Carson JAS, Wylie-Rosett J, Kushner RF, Lichtenstein AH, Devries S, Freeman AM, Crawford A, Kris-Etherton P, American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovasc Tags: Circulation Source Type: research

Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation.
CONCLUSIONS: -By identifying known drugs as potential therapeutics for CCM, we have decreased the time, cost, and risk of bringing treatments to patients. Each drug also prompts additional exploration of biomarkers of CCM disease. We further suggest that the structure-function screening platform presented here may be adapted and scaled to facilitate drug discovery for diverse loss-of-function genetic vascular disease. PMID: 25486933 [PubMed - as supplied by publisher]
Source: Circulation - December 8, 2014 Category: Cardiology Authors: Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY Tags: Circulation Source Type: research

Eliminating Health Disparities: What Can We Learn from the Veterans Health Administration?
Abstract Cardiovascular disease (CVD) mortality has declined by more than 70% in the United States (U.S.) with over a 78% reduction in coronary heart disease (CHD) deaths since 1968.(1) Despite these remarkable improvements, it is well-established that not all populations benefit equally.(2,3) African Americans have higher all-cause and CVD mortality as well as increased CHD and stroke incidence compared to their white counterparts (Table 1).(2,4,5). PMID: 26384520 [PubMed - as supplied by publisher]
Source: Circulation - September 18, 2015 Category: Cardiology Authors: Cook NL, Mensah GA Tags: Circulation Source Type: research

The American Heart Association's New Institute for  Precision Cardiovascular Medicine.
The American Heart Association's New Institute for Precision Cardiovascular Medicine. Circulation. 2016 Nov 22;: Authors: Houser SR Abstract "One size does not fit all." These 6 simple words represent the fundamental concept driving an unprecedented initiative of the American Heart Association, the Institute for Precision Cardiovascular Medicine. In the field of heart disease and stroke research, we have seen enormous knowledge advances in recent decades, all of which have led to breakthroughs in our ability to treat and prevent these illnesses. We celebrate these advances because they are allowing u...
Source: Circulation - November 21, 2016 Category: Cardiology Authors: Houser SR Tags: Circulation Source Type: research

Validity of Cardiovascular Data From Electronic Sources:The Multi-Ethnic Study of Atherosclerosis and HealthLNK.
Conclusions -These findings illustrate the limitations and strengths of electronic data repositories compared with information collected by traditional standardized epidemiologic approaches for the ascertainment of CVD risk factors and events. PMID: 28687707 [PubMed - as supplied by publisher]
Source: Circulation - July 7, 2017 Category: Cardiology Authors: Ahmad FS, Chan C, Rosenman MB, Post WS, Fort DG, Greenland P, Liu KJ, Kho A, Allen NB Tags: Circulation Source Type: research

Resuscitation Education Science: Educational Strategies to Improve Outcomes From Cardiac Arrest: A Scientific Statement From the American Heart Association.
Education Science and Programs Committee, Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research Abstract The formula for survival in resuscitation describes educational efficiency and local implementation as key determinants in survival after cardiac arrest. Current educational offerings in the form of standardized online and face-to-face courses are falling short, with providers demonstrating a decay of skills over time. This translates to suboptimal clinical care and poor survival outcomes fr...
Source: Circulation - June 21, 2018 Category: Cardiology Authors: Cheng A, Nadkarni VM, Mancini MB, Hunt EA, Sinz EH, Merchant RM, Donoghue A, Duff JP, Eppich W, Auerbach M, Bigham BL, Blewer AL, Chan PS, Bhanji F, American Heart Association Education Science Investigators; and on behalf of the American Heart Associatio Tags: Circulation Source Type: research

Relative Prognostic Importance and Optimal Levels of Risk Factors for Mortality and Cardiovascular Outcomes in Type 1 Diabetes.
CONCLUSIONS: Glycated hemoglobin, albuminuria, duration of diabetes, systolic blood pressure and low-density lipoprotein cholesterol appear the most important predictors for mortality and cardiovascular outcomes in patients with type 1 diabetes. Lower levels for glycated hemoglobin, systolic blood pressure and low-density lipoprotein cholesterol than contemporary guideline target levels appear to be associated with significantly lower risk for outcomes. PMID: 30798638 [PubMed - as supplied by publisher]
Source: Circulation - February 25, 2019 Category: Cardiology Authors: Rawshani A, Rawshani A, Sattar N, Franzén S, McGuire DK, Eliasson B, Svensson AM, Zethelius B, Miftaraj M, Rosengren A, Gudbjörnsdottir S Tags: Circulation Source Type: research