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Source: Molecular Neurobiology
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A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5
Abstract Cdk5, a cyclin-dependent kinase family member, is a global orchestrator of neuronal cytoskeletal dynamics. During embryogenesis, Cdk5 is indispensable for brain development. In adults, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation, drug addiction, pain signaling, and long-term behavior changes through long-term potentiation and long-term depression, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity becomes deregulated in various brain disorders, including Alzheimer’s disease, Parkinson’s disease, Hunt...
Source: Molecular Neurobiology - March 5, 2016 Category: Neurology Source Type: research