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Linagliptin treatment improves cerebrovascular function and remodeling and restores reduced cerebral perfusion in type 2 diabetes.
In this study, we hypothesized that DPP-IV inhibition with linagliptin would improve impaired cerebral perfusion in diabetic rats as well as improve insulin-induced cerebrovascular relaxation and reverse pathological cerebrovascular remodeling. We further postulated that these changes would lead to a subsequent improvement of cognitive function. Male type-2 diabetic and nondiabetic Goto-Kakizaki (GK) rats were treated with linagliptin for four weeks, and blood glucose and DPP-IV plasma levels were assessed. Cerebral perfusion was assessed post-treatment using laser Doppler imaging, and dose response to insulin (10(-13)- 10...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - June 28, 2016 Category: Physiology Authors: Hardigan T, Yasir A, Abdelsaid M, Coucha M, El-Shaffey S, Li W, Johnson MH, Ergul A Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Linagliptin treatment improves cerebrovascular function and remodeling and restores reduced cerebral perfusion in Type 2 diabetes
In this study, we hypothesized that DPP-IV inhibition with linagliptin would improve impaired cerebral perfusion in diabetic rats, as well as improve insulin-induced cerebrovascular relaxation and reverse pathological cerebrovascular remodeling. We further postulated that these changes would lead to a subsequent improvement of cognitive function. Male Type-2 diabetic and nondiabetic Goto-Kakizaki rats were treated with linagliptin for 4 wk, and blood glucose and DPP-IV plasma levels were assessed. Cerebral perfusion was assessed after treatment using laser-Doppler imaging, and dose response to insulin (10–13 M–...
Source: AJP: Regulatory, Integrative and Comparative Physiology - August 31, 2016 Category: Physiology Authors: Hardigan, T., Yasir, A., Abdelsaid, M., Coucha, M., El-Shaffey, S., Li, W., Johnson, M. H., Ergul, A. Tags: Obesity, Diabetes and Energy Homeostasis Source Type: research

Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs
Conclusion The use of optical non-invasive diagnostic methods has a great potential for the detection of concomitant microcirculation disorders in patients with rheumatic diseases and diabetes. In this review, it was shown that the use of laser Doppler flowmetry, optical tissue oximetry and fluorescence spectroscopy together or separately may have important diagnostic value for the detection of violations, assessment of their severity, as well as for the analysis of the effectiveness of the therapy. The joint application of the considered technologies with the methods of machine learning (discriminant analysis) can be use...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research