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A novel pharmacodynamic model in rats for preventing vascular dementia from maintaining neurovascular coupling sensitivity.
This study aimed to confirm a model for preventing VaD via maintaing NVC sensitivity in rats. The model was replicated with autologous microthrombi against the background of hypercholesterolemia. A phosphodiesterase inhibitor (pentoxyfylline) was preventively administrated to confirm the role of NVC sensitivity. Cognitive function was evaluated as exploratory, learning and memorizing abilities. NVC sensitivity was defined as the ratio of microcirculative cerebral blood flow (∆CBF) to the quantitative electroencephalograph (∆qEEG) before and after penicillin stimulation. The pathogenesis of NVC dysfunction was explored ...
Source: European Journal of Pharmacology - March 8, 2018 Category: Drugs & Pharmacology Authors: Zhao X, Liu J, Yang S, Song D, Wang C, Chen C, Wang C, Pu F, Yang R, Li X, Wang Q, Ge S, Lin Y, Liu X, Cai D Tags: Eur J Pharmacol Source Type: research

Ling-Yang-Gou-Teng-decoction prevents vascular dementia through inhibiting oxidative stress induced neurovascular coupling dysfunction
Conclusions The results suggested that LG prevented VaD may associate with inhibiting oxidative stress, protecting NO bioavailability, and then maintaining NVC sensitivity. Graphical abstract
Source: Journal of Ethnopharmacology - May 26, 2018 Category: Drugs & Pharmacology Source Type: research