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Training and teaching of vagus nerve stimulation surgery: worldwide survey and future perspectives
CONCLUSIONS: VNS surgery should be mastered by actively participating in dedicated practical training courses and by individual mentoring during actual surgery, which is still the best way to learn. This study highlights the need for a formal training course and possible specific accreditation.PMID:36775121 | DOI:10.1016/j.neuchi.2023.101420
Source: Neuro-Chirurgie - February 12, 2023 Category: Neurosurgery Authors: Marc Zanello Maxine Dibu é Erwin Cornips Alexandre Roux Aileen Mcgonigal Johan Pallud Romain Carron Source Type: research

Molecules, Vol. 27, Pages 7174: Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder
l Akour Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a substantially increasing incidence rate. It is characterized by repetitive behavior, learning difficulties, deficits in social communication, and interactions. Numerous medications, dietary supplements, and behavioral treatments have been recommended for the management of this condition, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory effects, such as downregulating the express...
Source: Molecules - October 23, 2022 Category: Chemistry Authors: Mohammed Moutaz Nakhal Salahdein Aburuz Bassem Sadek Amal Akour Tags: Review Source Type: research

Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years
Conclusions This is an under-reported research area and the findings suggest the codes’ usage diversity for most conditions remained overall stable throughout the study period. Generated mental health code lists can last for a long time unlike cardiometabolic conditions and cancer. Adopting more consistent and less diverse coding would help improve data quality in primary care. Future research is needed following the transfer to the Systematised Nomenclature of Medicine Clinical Terms (SNOMED CT) coding.
Source: BMJ Open - July 25, 2022 Category: General Medicine Authors: Zghebi, S. S., Reeves, D., Grigoroglou, C., McMillan, B., Ashcroft, D. M., Parisi, R., Kontopantelis, E. Tags: Open access, General practice / Family practice Source Type: research

New ERLEADA ® (apalutamide) Analysis Demonstrates Rapid, Deep Prostate-Specific Antigen (PSA) Response in Patients with Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
SAN FRANCISCO, Feb. 14, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new real-world evidence data showing the initiation of ERLEADA® (apalutamide) results in high rates of rapid and deep prostate-specific antigen (PSA) response among patients with metastatic castration-sensitive prostate cancer (mCSPC). In a separate post-hoc analysis of the registrational Phase 3 SPARTAN and TITAN studies, rapid and deep PSA responses with ERLEADA® were associated with improvement in patient-reported outcomes (PROs) related to quality of life, physical wellbeing, pain, and fatigue intensity. The...
Source: Johnson and Johnson - February 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Man
Adv Exp Med Biol. 2021;1349:165-192. doi: 10.1007/978-981-16-4254-8_9.ABSTRACTDEG/ENaC channels are voltage-independent Na+/Ca2+ channels that are conserved across species and are expressed in many different cell types and tissues, where they contribute to a wide array of physiological functions from transepithelial Na+ transport, to sensory perception, and learning and memory. In this chapter, we focus on the members of this family that are expressed in the nervous system, grouping them based on their function. Structurally, DEG/ENaC channels are trimers formed by either identical or homologous subunits, each one protrudi...
Source: Advances in Experimental Medicine and Biology - February 9, 2022 Category: Research Authors: Laura Bianchi Source Type: research

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