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Condition: Post Traumatic Stress Disorder
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The role of GFAP and vimentin in learning and memory.
Authors: Wilhelmsson U, Pozo-Rodrigalvarez A, Kalm M, Pablo Y, Widestrand Å, Pekna M, Pekny M
Abstract
Intermediate filaments (also termed nanofilaments) are involved in many cellular functions and play important roles in cellular responses to stress. The upregulation of glial fibrillary acidic protein (GFAP) and vimentin (Vim), intermediate filament proteins of astrocytes, is the hallmark of astrocyte activation and reactive gliosis in response to injury, ischemia or neurodegeneration. Reactive gliosis is essential for the protective role of astrocytes at acute stages of neurotrauma or ischemic stroke. However, G...
Source: Biological Chemistry - May 9, 2019 Category: Chemistry Tags: Biol Chem Source Type: research
