The role of GFAP and vimentin in learning and memory.

The role of GFAP and vimentin in learning and memory. Biol Chem. 2019 May 01;: Authors: Wilhelmsson U, Pozo-Rodrigalvarez A, Kalm M, Pablo Y, Widestrand Å, Pekna M, Pekny M Abstract Intermediate filaments (also termed nanofilaments) are involved in many cellular functions and play important roles in cellular responses to stress. The upregulation of glial fibrillary acidic protein (GFAP) and vimentin (Vim), intermediate filament proteins of astrocytes, is the hallmark of astrocyte activation and reactive gliosis in response to injury, ischemia or neurodegeneration. Reactive gliosis is essential for the protective role of astrocytes at acute stages of neurotrauma or ischemic stroke. However, GFAP and Vim were also linked to neural plasticity and regenerative responses in healthy and injured brain. Mice deficient for GFAP and vimentin (GFAP-/-Vim-/-) exhibit increased post-traumatic synaptic plasticity and increased basal and post-traumatic hippocampal neurogenesis. Here we assessed the locomotor and exploratory behavior of GFAP-/-Vim-/- mice, their learning, memory, and memory extinction, by using the open field, object recognition and Morris water maze tests, trace fear conditioning, and by recording reversal learning in Intellicages. While the locomotion, exploratory behavior and learning of GFAP-/-Vim-/- mice, as assessed by object recognition, Morris water maze, and trace fear conditioning tests, were comparable to wildtype mice, ...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research