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Total 7778 results found since Jan 2013.

Use of Warfarin at Discharge Among Acute Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation in China Clinical Sciences
Conclusions— The rate of warfarin use remains low among patients with ischemic stroke and known nonvalvular atrial fibrillation in China. Hospital size and academic status together with patient age, heart failure, heavy alcohol drinking, international normalized ratio in hospital, and stroke severity on admission were each independently associated with the use of warfarin at discharge. There is much room for improvement for secondary stroke prevention in nonvalvular atrial fibrillation patients in China.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Yang, X., Li, Z., Zhao, X., Wang, C., Liu, L., Wang, C., Pan, Y., Li, H., Wang, D., Hart, R. G., Wang, Y., Wang, Y., on behalf of the China National Stroke Registry II Investigators Tags: Anticoagulants, Treatment, Quality and Outcomes, Ischemic Stroke Clinical Sciences Source Type: research

Urgent Carotid Surgery and Stenting May Be Safe After Systemic Thrombolysis for Stroke Clinical Sciences
Conclusions— Urgent carotid endarterectomy or carotid artery stenting after thrombolysis for stroke may be safe without increased risk of serious complications.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Koraen-Smith, L., Troeng, T., Bjorck, M., Kragsterman, B., Wahlgren, C.-M., on behalf of the Swedish Vascular Registry and the Riks-Stroke Collaboration, This work was supported by the Steering Committee of the Swedish Vascular Registry (Swedvasc):, Krags Tags: Acute Cerebral Infarction, Carotid Stenosis, Emergency treatment of Stroke, Carotid endarterectomy, Angioplasty and Stenting Clinical Sciences Source Type: research

Effectiveness and Safety of Apixaban, Dabigatran, and Rivaroxaban Versus Warfarin in Patients With Nonvalvular Atrial Fibrillation and Previous Stroke or Transient Ischemic Attack Clinical Sciences
Conclusions—Results from our study of the 3 NOACs versus warfarin in nonvalvular atrial fibrillation patients with a previous history of stroke/transient ischemic attack are relatively consistent with their respective phase III trials and previous stroke/transient ischemic attack subgroup analyses. All NOACs seemed no worse than warfarin in respect to ischemic stroke, ICH, or major bleeding risk.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Craig I. Coleman, W. Frank Peacock, Thomas J. Bunz, Mark J. Alberts Tags: Arrhythmias, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Post Stroke Use of Selective Serotonin Reuptake Inhibitors and Clinical Outcome Among Patients With Ischemic Stroke: A Nationwide Propensity Score-matched Follow-up Study Original Contributions
Conclusions— SSRI use after ischemic stroke was associated with a lower risk of new cardiovascular events and also with an increased bleeding risk. There was an increased mortality among SSRI users, which may be related to the increased bleeding risk.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Mortensen, J. K., Larsson, H., Johnsen, S. P., Andersen, G. Tags: Secondary prevention, Cerebrovascular disease/stroke, Platelet function inhibitors, Antiplatelets, Neuroprotectors Original Contributions Source Type: research

Predictors for Symptomatic Intracranial Hemorrhage After Endovascular Treatment of Acute Ischemic Stroke Clinical Sciences
Conclusions—Incidence of SICH after thrombectomy is higher in Asian patients with acute ischemic stroke. Cardioembolic stroke, poor collateral circulation, delayed endovascular treatment, multiple passes with stent retriever device, lower pretreatment Alberta Stroke Program Early Computed Tomography Score, higher baseline neutrophil ratio may increase the risk of SICH.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Yonggang Hao, Dong Yang, Huaiming Wang, Wenjie Zi, Meng Zhang, Yu Geng, Zhiming Zhou, Wei Wang, Haowen Xu, Xiguang Tian, Penghua Lv, Yuxiu Liu, Yunyun Xiong, Xinfeng Liu, Gelin Xu, for the ACTUAL Investigators (Endovascular Treatment for Acute Anterior C Tags: Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Thrombolysis in Postoperative Stroke Clinical Sciences
Conclusions—IVT may be administered safely in postoperative patients as off-label use after appropriate risk–benefit assessment. However, bleeding risk in surgical area should be taken into account particularly in patients who have undergone surgery shortly before stroke onset.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Nicolas Voelkel, Nikolai Dominik Hubert, Roland Backhaus, Roman Ludwig Haberl, Gordian Jan Hubert Tags: Complications, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Continuation or Discontinuation of Anticoagulation in the Early Phase After Acute Ischemic Stroke Brief Report
Background and Purpose—There is no consensus on whether anticoagulation should be continued or temporarily stopped in patients suffering acute ischemic stroke while using anticoagulation. We assessed treatment variations and outcomes in these patients.Methods—Post hoc analysis of PASS (Preventive Antibiotics in Stroke Study). We included patients with acute ischemic stroke who used anticoagulation at admission. We compared clinical outcomes, thrombotic, and major bleeding events at 3 months.Results—Nine percent (192/2101) of the patients with acute ischemic stroke used anticoagulation at admission (186 vitamin K anta...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Adrien E. Groot, Jan-Dirk M. Vermeij, Willeke F. Westendorp, Paul J. Nederkoorn, Diederik van de Beek, Jonathan M. Coutinho Tags: Secondary Prevention, Anticoagulants, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Interrelationship Among Common Medical Complications After Acute Stroke: Pneumonia Plays an Important Role Clinical Sciences
Conclusions— Pneumonia is closely associated with the development of several nonpneumonia medical complications after AIS and ICH.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Ji, R., Wang, D., Shen, H., Pan, Y., Liu, G., Wang, P., Wang, Y., Li, H., Wang, Y., on behalf of China National Stroke Registry (CNSR) Investigators Tags: Clinical Sciences Source Type: research

Repeated Intravenous Thrombolysis for Early Recurrent Stroke: Challenging the Exclusion Criterion Brief Reports
Conclusions— Patients with small infarct volumes and robust clinical improvement might be considered for repeated IVT within 3 months. Studies following strict protocols and larger registries incorporating these patients might serve to identify selection criteria for the safe use of repeated IVT in ERS.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Kahles, T., Mono, M.-L., Heldner, M. R., Baumgartner, R. W., Sarikaya, H., Luft, A., Bohlhalter, S., Traenka, C., Engelter, S. T., Kurka, N., Kohrmann, M., Curtze, S., Michel, P., Tatlisumak, T., Nedeltchev, K. Tags: Treatment, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Brief Reports Source Type: research

Venous Thromboembolism Risk in Ischemic Stroke Patients Receiving Extended-Duration Enoxaparin Prophylaxis: Results From the EXCLAIM Study Brief Reports
Conclusion— Extended-duration thromboprophylaxis with enoxaparin was associated with reduced venous thromboembolism risk and increased major bleeding in the subgroup of patients with ischemic stroke in the EXCLAIM study. Clinical Trial Registration Information— URL: http://clinicaltrials.gov. Unique Identifier: NCT00077753.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Turpie, A. G. G., Hull, R. D., Schellong, S. M., Tapson, V. F., Monreal, M., Samama, M.-M., Chen, M., Yusen, R. D., for the EXCLAIM Investigators Tags: Cerebrovascular disease/stroke, Deep vein thrombosis, Anticoagulants Brief Reports Source Type: research

The iScore Predicts Efficacy and Risk of Bleeding in the National Institute of Neurological Disorders and Stroke Tissue Plasminogen Activator Stroke Trial
The iScore is a validated tool to estimate outcomes after an acute ischemic stroke. A previous study showed the iScore can predict clinical response and risk of intracerebral hemorrhage (ICH) after administration of tissue plasminogen activator (tPA). We applied the iScore (www.sorcan.ca/iscore) to participants in the National Institute of Neurological Disorders and Stroke tPA stroke trials to evaluate its ability to estimate clinical response and risk of ICH after thrombolysis. Based on results from our previous study, patients were stratified a priori into iScore
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2012 Category: Neurology Authors: Gustavo Saposnik, Andrew Demchuk, Jack V. Tu, S. Claiborne Johnston, Stroke Outcomes Research Canada (SORCan) Working Group Tags: Original Articles Source Type: research

Race/Ethnic Differences in the Risk of Hemorrhagic Complications Among Patients With Ischemic Stroke Receiving Thrombolytic Therapy Clinical Sciences
Conclusions— In patients with stroke receiving tPA, hemorrhagic complications were slightly higher in blacks and Asians, but not in Hispanics compared with whites. Asians also faced significantly higher risk for sICH relative to other race/ethnic groups. Future studies are needed to evaluate whether reduction in tPA dose similar to that used in many Asian countries could improve the safety of tPA therapy in Asians in the United States with acute ischemic strokes while maintaining efficacy.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Mehta, R. H., Cox, M., Smith, E. E., Xian, Y., Bhatt, D. L., Fonarow, G. C., Peterson, E. D., for the Get With The Guidelines-Stroke Program Tags: Thrombolysis Clinical Sciences Source Type: research

Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke Brief Report
Conclusions—Our results demonstrate TLR4 involvement in hemorrhagic transformation induced by delayed tPA administration, very likely by increasing matrix metalloproteinase 9 expression.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Alicia Garcia–Culebras, Sara Palma–Tortosa, Ana Moraga, Isaac Garcia–Yebenes, Violeta Duran–Laforet, Maria I. Cuartero, Juan de la Parra, Ana L. Barrios–Munoz, Jaime Diaz–Guzman, Jesus M. Pradillo, Maria A. Moro, Ignaci Tags: Blood-Brain Barrier, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

External Validation of Risk Scores for Major Bleeding in a Population-Based Cohort of Transient Ischemic Attack and Ischemic Stroke Patients Clinical Sciences
Conclusions—The S2TOP-BLEED score shows modest performance in a population-based cohort of patients with a transient ischemic attack or ischemic stroke. Although bleeding risks were associated with risks of ischemic events, risk stratification may still be useful to identify a subgroup of patients at particularly high risk of bleeding, in whom preventive measures are indicated.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Nina A. Hilkens, Linxin Li, Peter M. Rothwell, Ale Algra, Jacoba P. Greving Tags: Risk Factors, Secondary Prevention, Ischemic Stroke Original Contributions Source Type: research

Continuous Antihypertensive Therapy Throughout the Initial 24 Hours of Intracerebral Hemorrhage: The Stroke Acute Management With Urgent Risk-Factor Assessment and Improvement-Intracerebral Hemorrhage Study Brief Reports
Conclusions— The continuation of AHT throughout the initial 24 hours after ICH may improve outcomes.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Kobayashi, J., Koga, M., Tanaka, E., Okada, Y., Kimura, K., Yamagami, H., Okuda, S., Hasegawa, Y., Shiokawa, Y., Furui, E., Nakagawara, J., Kario, K., Okata, T., Arihiro, S., Sato, S., Nagatsuka, K., Minematsu, K., Toyoda, K., for the SAMURAI Study Invest Tags: Acute Cerebral Hemorrhage, Emergency treatment of Stroke, Other Stroke Treatment - Medical Brief Reports Source Type: research