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Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents
Drug Metab Pharmacokinet. 2021 Mar 20;38:100390. doi: 10.1016/j.dmpk.2021.100390. Online ahead of print.ABSTRACTThe combination of antiarrhythmic agents, amiodarone or dronedarone, with the anticoagulant rivaroxaban is used clinically in the management of atrial fibrillation for rhythm control and secondary stroke prevention respectively. Renal drug-drug interactions (DDIs) between amiodarone or dronedarone and rivaroxaban were previously ascribed to inhibition of rivaroxaban secretion by P-glycoprotein at the apical membrane of renal proximal tubular epithelial cells. Benzbromarone, a known inhibitor of organic anion tran...
Source: Drug Metabolism and Pharmacokinetics - April 9, 2021 Category: Drugs & Pharmacology Authors: Heng Lin Tan Lloyd Wei Tat Tang Sheng Yuan Chin Eric Chun Yong Chan Source Type: research

Strategies to balance stroke and bleeding risk in patients with atrial fibrillation and cancer
A 76-year-old female with obesity, hypertension, persistent atrial fibrillation, and heart failure with preserved ejection fraction is started on ibrutinib 420 mg once daily for Waldenstrom ’s macroglobulinemia. Due to concern for drug-drug interactions, her amiodarone is decreased from 200 to 100 mg daily, and she is continued on metoprolol succinate 100 mg daily and apixaban 5 mg twice daily. She presents to the clinic one month later with extensive superficial ecchymoses, and her apixaban dose is reduced to 2.5 mg twice daily due to concerns that this may reflect the combined antiplatelet effects of ibrutinib and anti...
Source: Heart Rhythm - April 27, 2021 Category: Cardiology Authors: Shiv Bagga, Sourbha S. Dani, Bruce G. Hook, Anju Nohria, Sarju Ganatra Source Type: research

Subclinical Thyroid Function and Cardiovascular Events in patients with Atrial Fibrillation
CONCLUSIONS: Subclinical hypothyroidism was not associated with increased CV risk in AF patients. Higher levels of fT4 with normal TSH were associated with higher risk for HF.PMID:34228632 | DOI:10.1530/EJE-20-1442
Source: European Journal of Endocrinology - July 6, 2021 Category: Endocrinology Authors: Elisavet Moutzouri Christina Lyko Martin Feller Manuel Raphael Blum Luise Adam Steffen Blum Stefanie Aeschbacher Urs Fischer Laurent Roten Cinzia Del Giovane Christine S Meyer-Zuern Giulio Conte Leo H Bonati Giorgio Moschovitis Michael Kuehne Juerg Beer D Source Type: research

Cancers, Vol. 13, Pages 4012: Atrial Fibrillation after Lung Cancer Surgery: Prediction, Prevention, and Anticoagulation Management
rdinale Atrial fibrillation (AF) is a common complication of the early postoperative period of various types of surgery, including that for lung cancer. Although induced by the homeostatic alterations related to surgery, there is evidence that it is not a mere stand-alone transitory event, but it represents a relevant complication of surgery, bearing considerable prognostic consequences. Different methods have therefore been explored to predict the occurrence of postoperative atrial fibrillation (POAF) and prevent it. In particular, the age among clinical factors, and N-terminal prohormone of brain natriuretic peptide ...
Source: Cancers - August 9, 2021 Category: Cancer & Oncology Authors: Gennaro Semeraro Carlo Meroni Carlo Cipolla Daniela Cardinale Tags: Review Source Type: research

Cancers, Vol. 13, Pages 4012: Atrial Fibrillation after Lung Cancer Surgery: Prediction, Prevention and Anticoagulation Management
rdinale Atrial fibrillation (AF) is a common complication of the early postoperative period of various types of surgery, including that for lung cancer. Although induced by the homeostatic alterations related to surgery, there is evidence that it is not a mere stand-alone transitory event, but it represents a relevant complication of surgery, bearing considerable prognostic consequences. Different methods have therefore been explored to predict the occurrence of postoperative atrial fibrillation (POAF) and prevent it. In particular, the age among clinical factors, and N-terminal prohormone of brain natriuretic peptide ...
Source: Cancers - August 9, 2021 Category: Cancer & Oncology Authors: Gennaro Carmine Semeraro Carlo Ambrogio Meroni Carlo Maria Cipolla Daniela Maria Cardinale Tags: Review Source Type: research

Pharmacological interventions for preventing atrial fibrillation after lung surgery: systematic review and meta-analysis
ConclusionCurrent clinical evidence supports the effectiveness of pharmacological intervention with beta-blockers, amiodarone, magnesium sulfate, or calcium-channel blockers to reduce the incidence of POAF after lung surgery in patients with lung cancer. In the absence of contraindications, prophylaxis with beta-blockers seems to be the most effective of the treatments studied.
Source: European Journal of Clinical Pharmacology - September 22, 2022 Category: Drugs & Pharmacology Source Type: research

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