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Medical management of critical limb ischaemia: where do we stand today?
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - June 26, 2013 Category: Internal Medicine Authors: Matthew A. Lambert, Jill J. F. Belch Tags: Review Source Type: research

Inflammatory hypertrophic cauda equina syndrome following intrathecal neural stem cell injection
Conclusions: Safety of intrathecal stem cell treatments is not routinely regulated in commercial overseas stem cell facilities. We wish to bring this potential complication to the attention of health care providers. Muscle Nerve, 2013
Source: Muscle and Nerve - June 26, 2013 Category: Internal Medicine Authors: Richard W. Hurst, E. Peter Bosch, Jonathan M. Morris, P. James B. Dyck, Ronald K. Reeves Tags: Case of the Month Source Type: research

Inflammatory hypertrophic cauda equina following intrathecal neural stem cell injection
We describe a woman who presented with progressive bilateral leg pain, numbness, and gait difficulties. A prior stroke, macular degeneration, osteoarthritis, and depression, led her to receive intrathecal neural stem cell therapy overseas 1 year prior to onset of symptoms. Imaging showed marked enlargement of lumbosacral roots of the cauda equina, which was not seen prior to stem cell treatment. Electrodiagnostic studies confirmed chronic multiple lumbosacral radiculopathies. Biopsy of a lumbar dorsal sensory root showed myelinated fiber degeneration and loss, with endoneurial inflammation. The hypertrophic inflammatory ca...
Source: Muscle and Nerve - June 1, 2013 Category: Internal Medicine Authors: Richard W. Hurst, Jonathan M. Morris, P James B Dyck, E. Peter Bosch, Ronald K. Reeves Tags: Case of the Month Source Type: research

Long‐term outcome of enzyme‐replacement therapy in advanced Fabry disease: evidence for disease progression towards serious complications
ConclusionDespite ERT, clinically meaningful events including sudden cardiac death continue to develop in patients with advanced Fabry disease.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - April 1, 2013 Category: Internal Medicine Authors: Frank Weidemann, Markus Niemann, Stefan Störk, Frank Breunig, Meinrad Beer, Claudia Sommer, Sebastian Herrmann, Georg Ertl, Christoph Wanner Tags: Original Article Source Type: research

Prophylactic dose fondaparinux for 6 weeks in superficial thrombophlebitis of the legs reduces the risk for symptomatic thromboembolic complications
Commentary on: Di Nisio M, Wichers IM, Middeldorp S. Treatment for superficial thrombophlebitis of the leg. Cochrane Database Syst Rev 2012;3:CD004982. Context Superficial thrombophlebitis (ST), an inflammatory-thrombotic disorder in a superficial vein, is relatively common and estimated to occur in 1 per 1000 persons.1 The classic symptoms include pain, oedema, erythema and occasionally a palpable cord in the area of the thrombosed vein. Risk factors for ST include surgery, pregnancy and puerperium, female hormones, malignancy, infection, varicose veins, autoimmune disorders and thrombophilia.2 ST is a risk factor for dee...
Source: Evidence-Based Medicine - January 17, 2013 Category: Internal Medicine Authors: DeSancho, M. T., Pastores, S. M. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Pain (neurology), Stroke, Pregnancy, Venous thromboembolism, Renal medicine, Pulmonary embolism, Drugs: musculoskeletal and joint diseases, Dermatology Therapeutics Source Type: research

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