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Condition: Pain
Drug: Ibuprofen

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Total 58 results found since Jan 2013.

FDA strengthens warning that NSAIDs increase heart attack and stroke risk
Back in 2005, the FDA warned that taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen increased the risk of having a heart attack or stroke. Last week it took the unusual step of further strengthening this warning. This was done on the advice of an expert panel that reviewed new information about NSAIDs and their risks. Because NSAIDs are widely used, it’s important to be aware of downsides of taking an NSAID and to take steps to limit the risk. Many people take NSAIDs to relieve mild to moderate pain. These medications may be particularly effective in conditions in which pain results pri...
Source: New Harvard Health Information - July 13, 2015 Category: Consumer Health News Authors: Gregory Curfman, MD Tags: Heart Health heart attack heart disease NSAIDS Stroke Source Type: news

When Stroke Happens... at Age 27
Ever wonder what it's like to experience a stroke? Avid runner Emily Welbourn blogs about the day she had a stroke while running a race. At the sound of the starting gun, I charge forward with the other runners selected from around the world. In spite of being at peak physical health, I slowly realize my pace isn't sustainable. The one-mile marker is now ahead, I've got this. Just keep moving. Suddenly I am stabbed above the eyebrow...but no one is within arm's reach. Blindsided, I squeeze my eyes shut for a moment to tamper the pain, and the invisible knife is dragged across the top of my head down to my neck. Never i...
Source: Healthy Living - The Huffington Post - October 29, 2015 Category: Consumer Health News Source Type: news

Heart attack, stroke warning on pain relievers strengthened
Stephen FellerSILVER SPRING, Md., July 10 (UPI) -- The FDA is strengthening warnings on prescription and over-the-counter ibuprofen and naproxen pain relievers about increased risk for heart attack and stroke.
Source: Health News - UPI.com - July 10, 2015 Category: Consumer Health News Source Type: news

High salt levels in soluble drugs may raise heart risk
Conclusion This large case control study suggested that people who had experienced disease of the heart and blood vessels were more likely to have taken sodium-containing medicines than people without cardiovascular disease. Put in other words this can be interpreted that people who took sodium-containing medicines were at a higher risk of experiencing cardiovascular disease than people who took the same medications in formulations free of sodium. The increased risk appeared to be driven mostly by an increased risk of hypertension and to a lesser extent, non-fatal stroke. The study has some strengths including its large s...
Source: NHS News Feed - November 27, 2013 Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news

Is long-term paracetamol use not as safe as we thought?
Conclusion This is a valuable review that has searched the literature and identified eight observational studies in adults that have looked at the adverse effects that may be associated with paracetamol use. As the researchers say, it will add to information on the potential harms of paracetamol – an area where up-to-date information has been lacking. The studies included very large population sizes, and collectively provide some evidence suggesting potential effects upon the cardiovascular system, kidney and gastrointestinal system. There was also a suggestion of increased risk of all-cause mortality. However, it is v...
Source: NHS News Feed - March 3, 2015 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

High-dose painkiller heart risk: small but significant
Conclusion This large review adds to, and expands on, the current evidence on the risks of vascular disease and gastrointestinal complications for different NSAIDs. It largely concentrates on trials of high doses of NSAIDs that can only be prescribed by a doctor. It is unclear from this study whether there is any risk from taking lower doses available over the counter. While most experts advise that low-dose NSAIDs, taken occasionally, are safe for most people, an accompanying editorial points out that there are still “large gaps” in evidence on the risks with lower doses of NSAIDs. While the risk to individuals is sma...
Source: NHS News Feed - May 30, 2013 Category: Consumer Health News Tags: Medication Heart/lungs Source Type: news

Painkiller use linked to irregular heartbeat
ConclusionThis prospective cohort study claims an association between NSAIDs usage and developing atrial fibrillation. However, there are many limitations to this research.Despite this being a large prospective cohort study that followed people over a period of time, the assessments within it were predominantly cross-sectional. That means it assessed the person’s current or recent prescription of NSAIDs at the time they were diagnosed, but this cannot prove that using NSAIDs caused atrial fibrillation. A better method may have been to assess the use of NSAIDs in people without atrial fibrillation at the start of the stud...
Source: NHS News Feed - April 9, 2014 Category: Consumer Health News Tags: Heart/lungs Medication Older people Source Type: news

My debilitating endometriosis symptoms – Kate ’ s story
Hi, I’m Kate, 39, married with no children. I had always suffered from heavy and painful periods but this had mostly been managed by taking the combined pill. My periods remained heavy and I suffered from some flooding but this was manageable with planning! Approximately 7 years ago my periods became worse and I started to experience more symptoms such as regular and frequent abdominal pain, random bleeding, bloating, very painful intercourse and things just didn’t feel right. Anyway, I went to the Dr’s who straight away suggested that it sounded like I had endometriosis and referred me to a consultant. A...
Source: The Hysterectomy Association - March 1, 2017 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Health endometriosis hysterectomy stories Source Type: news

Preparation of well-defined ibuprofen prodrug micelles by RAFT polymerization.
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever and inflammation and are being explored in a new indication in cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage and elevated risk of stroke, however, can limit their use and exploration in new indications.　Here we report a facile method to prepare well-defined amphiphilic diblock copolymer NSAID prodrugs by direct reversible addition fragmentation transfer (RAFT) polymerization of the acrylamide derivative of ibuprofen (IBU), a widely used NSAID. The synthesis and self-as...
Source: Biomacromolecules - August 12, 2013 Category: Biochemistry Authors: Hasegawa U, van der Vlies AJ, Wandrey C, Hubbell JA Tags: Biomacromolecules Source Type: research

Taking over the counter pain relievers safely
For aching joints or a throbbing head, millions of Americans turn to aspirin, ibuprofen (Advil, Motrin), or other nonsteroidal anti-inflammatory drugs (NSAIDs) every day. They are generally safe, but if not used carefully NSAIDs can have a dark side, according to the September 2013 Harvard Women's Health Watch. NSAIDs are widely used because they perform double duty. “They not only relieve pain, but they reduce inflammation too,” says Dr. Lucy Chen, an assistant professor at Harvard Medical School and attending physician in the anesthesia, critical care, and pain medicine department at Massachusetts General Hos...
Source: New Harvard Health Information - August 23, 2013 Category: Consumer Health News Source Type: news

Some Pain Drugs Increase the Risk of Heart Attack
ROCHESTER, Minn. — Some of the most common pain drugs used by older adults who experience discomfort in muscles and joints can increase the risk of heart attack and stroke. The April issue of Mayo Clinic Health Letter covers the risks of nonsteroidal anti-inflammatory drugs (NSAIDs) that include celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin [...]
Source: Mayo Clinic Health Information - April 26, 2013 Category: Consumer Health News Source Type: news

Multimodal analgesia versus traditional opiate based analgesia after cardiac surgery, a randomized controlled trial
Background: To evaluate if an opiate sparing multimodal regimen of dexamethasone, gabapentin, ibuprofen and paracetamol had better analgesic effect, less side effects and was safe compared to a traditional morphine and paracetamol regimen after cardiac surgery. Methods: Open-label, prospective randomized controlled trial. 180 patients undergoing cardiac procedures through median sternotomy, were included in the period march 2007- August 2009. 151 patients were available for analysis. Pain was assessed with the 11-numeric rating scale (11-NRS). Results: Patients in the multimodal group demonstrated significantly lower avera...
Source: Journal of Cardiothoracic Surgery - March 20, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Sulman RafiqDaniel SteinbrüchelMichael WanscherLars AndersenAlbert NavneNikolaj LilleoerPeter Olsen Source Type: research