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Prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global longitudinal strain in a community‐based cohort
ConclusionIn a community‐based cohort, GLS‐LVSD was four times more frequent than LVEF‐LVSD. GLS‐LVSD was a powerful and independent predictor of cardiovascular events. Left ventricular function assessment by GLS may improve cardiovascular risk stratification in subjects with normal LVEF.
Source: European Journal of Heart Failure - September 11, 2014 Category: Cardiology Authors: Cesare Russo, Zhezhen Jin, Mitchell S.V. Elkind, Tatjana Rundek, Shunichi Homma, Ralph L. Sacco, Marco R. Di Tullio Tags: Original Article Source Type: research

Predictors of mortality in acute heart failure: interaction between diabetes and impaired left ventricular ejection fraction
ConclusionThe interaction of diabetes and impaired LVEF in acute heart failure patients significantly amplifies the deleterious effects of each as distinct disease entities.
Source: European Journal of Heart Failure - June 5, 2014 Category: Cardiology Authors: Yun Yun Go, John Carson Allen, Shaw Yang Chia, Ling Ling Sim, Fazlur Rehman Jaufeerally, Jonathan Yap, Chi Keong Ching, David Sim, Bernard Kwok, Reginald Liew Tags: Original Article Source Type: research

Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension
ConclusionsPAH is associated with impaired biventricular deformation. Reduction in PVR is associated with improvements in both RV and LV deformation, coupled to improvements in MPAP and stroke volume index, with LV global and septal CS the strongest correlates of these changes. RV FWLS is sensitive to treatment effect, demonstrating greater improvement with imatinib compared with placebo.Trial registration: NCT00902174
Source: European Journal of Heart Failure - November 1, 2014 Category: Cardiology Authors: Gabriela Querejeta Roca, Patricia Campbell, Brian Claggett, Ali Vazir, Debbie Quinn, Scott D. Solomon, Amil M. Shah Tags: Original Article Source Type: research

Fruit and vegetable intake and rate of heart failure: a population‐based prospective cohort of women
ConclusionsIn this population‐based prospective cohort study of women, higher total consumption of fruit and vegetables was inversely associated with the incidence of heart failure.
Source: European Journal of Heart Failure - November 1, 2014 Category: Cardiology Authors: Susanne Rautiainen, Emily B. Levitan, Murray A. Mittleman, Alicja Wolk Tags: Original Article Source Type: research

Telomere length and outcomes in ischaemic heart failure: data from the COntrolled ROsuvastatin multiNAtional Trial in Heart Failure (CORONA)
ConclusionBiological age as defined by leucocyte telomere length was associated with clinical outcomes in patients with ischaemic heart failure, but this association did not add prognostic information above age as defined by date of birth.
Source: European Journal of Heart Failure - January 1, 2015 Category: Cardiology Authors: Vincent G. Haver, Irene Mateo Leach, John Kjekshus, Jayne C. Fox, Hans Wedel, John Wikstrand, Rudolf A. de Boer, Wiek H. van Gilst, John J.V. McMurray, Dirk J. van Veldhuisen, Pim van der Harst Tags: Original Article Source Type: research

Sex differences in clinical characteristics and outcomes after myocardial infarction: insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT)
ConclusionsIn VALIANT, the risk of HF following MI was higher in women than men after adjusting for age and comorbidities, although the risk of other fatal and non‐fatal outcomes were similar. The higher long‐term risk of HF in women appears to be independent of the extent of left ventricular systolic dysfunction or remodelling compared with men.
Source: European Journal of Heart Failure - February 6, 2015 Category: Cardiology Authors: Carolyn S. P. Lam, Margaret McEntegart, Brian Claggett, Jiankang Liu, Hicham Skali, Eldrin Lewis, Lars Køber, Jean Rouleau, Eric Velazquez, Rob Califf, John J. McMurray, Marc Pfeffer, Scott Solomon Tags: Original Article Source Type: research

Do statins reduce the risk of myocardial infarction in patients with heart failure? A pooled individual‐level reanalysis of CORONA and GISSI‐HF
ConclusionThis individual‐level reanalysis of two landmark trials demonstrates a small but statistically significant decreased risk for MI among patients with ischaemic HF randomized to rosuvastatin vs. placebo. Rosuvastatin appears to be effective in preventing MI in ischaemic HF patients not already on statins.
Source: European Journal of Heart Failure - February 1, 2015 Category: Cardiology Authors: Matthew J. Feinstein, Pardeep Jhund, Joseph Kang, Hongyan Ning, Aldo Maggioni, John Wikstrand, John Kjekshus, Luigi Tavazzi, John McMurray, Donald M. Lloyd‐Jones Tags: Original Article Source Type: research

Heart failure in patients with atrial fibrillation in Europe: a report from the EURObservational Research Programme Pilot survey on Atrial Fibrillation
ConclusionWe provide insights into the clinical characteristics and outcomes in AF patients with HF, who were managed by European cardiologists. Despite a high prevalence of oral anticoagulant use, 1‐year mortality and morbidity remained high in AF patients with HF, whether HFrEF or HFpEF. Such patients require a holistic approach to cardiovascular risk management.
Source: European Journal of Heart Failure - March 2, 2015 Category: Cardiology Authors: Gregory Y.H. Lip, Cécile Laroche, Mircea I. Popescu, Lars H. Rasmussen, Laura Vitali‐Serdoz, Gheorghe‐Andrei Dan, Zbigniew Kalarus, Harry J.G.M. Crijns, Mario M. Oliveira, Luigi Tavazzi, Aldo P. Maggioni, Giuseppe Boriani Tags: Original Article Source Type: research

High serum erythropoietin levels are related to heart failure development in subjects from the general population with albuminuria: data from PREVEND
ConclusionHigh serum EPO levels are independently associated with an increased risk of new‐onset HF in subjects with albuminuria. More research into the pathophysiological mechanisms linking EPO levels to HF is needed to understand this association.
Source: European Journal of Heart Failure - January 18, 2016 Category: Cardiology Authors: Niels Grote Beverborg, Haye H. van der Wal, IJsbrand T. Klip, Adriaan A. Voors, Rudolf A. de Boer, Wiek H. van Gilst, Dirk J. van Veldhuisen, Ron T. Gansevoort, Hans L. Hillege, Pim van der Harst, Stephan J.L. Bakker, Peter van der Meer Tags: Original Article Source Type: research

Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology
Acute right ventricular (RV) failure is a complex clinical syndrome that results from many causes. Research efforts have disproportionately focused on the failing left ventricle, but recently the need has been recognized to achieve a more comprehensive understanding of RV anatomy, physiology, and pathophysiology, and of management approaches. Right ventricular mechanics and function are altered in the setting of either pressure overload or volume overload. Failure may also result from a primary reduction of myocardial contractility owing to ischaemia, cardiomyopathy, or arrhythmia. Dysfunction leads to impaired RV filling ...
Source: European Journal of Heart Failure - March 15, 2016 Category: Cardiology Authors: Veli‐Pekka Harjola, Alexandre Mebazaa, Jelena Čelutkienė, Dominique Bettex, Hector Bueno, Ovidiu Chioncel, Maria G. Crespo‐Leiro, Volkmar Falk, Gerasimos Filippatos, Simon Gibbs, Adelino Leite‐Moreira, Johan Lassus, Josep Masip, Christian Mueller, Tags: Statement Source Type: research

Clinical significance of pulse pressure in patients with heart failure with preserved left ventricular ejection fraction
ConclusionPulse pressure lower than 45 mmHg and higher than 75 mmHg was closely associated with HFpEF prognosis, indicating the clinical significance of PP for risk stratification of HFpEF.
Source: European Journal of Heart Failure - May 14, 2016 Category: Cardiology Authors: Takanori Tokitsu, Eiichiro Yamamoto, Yoshihiro Hirata, Hiroaki Kusaka, Koichiro Fujisue, Daisuke Sueta, Koichi Sugamura, Kenji Sakamoto, Kenichi Tsujita, Koichi Kaikita, Seiji Hokimoto, Seigo Sugiyama, Hisao Ogawa Tags: Original Article Source Type: research

Stroke prevention in heart failure and sinus rhythm: where do we go from here?
Source: European Journal of Heart Failure - October 3, 2016 Category: Cardiology Authors: Muthiah Vaduganathan, Ravi B. Patel, Clyde W. Yancy Tags: Editorial comment Source Type: research

Left ventricular deformation at rest predicts exercise ‐induced elevation in pulmonary artery wedge pressure in patients with unexplained dyspnoea
ConclusionLeft ventricular deformation at rest predicts exercise‐induced rise in PAWP among patients with dyspnoea and a preserved LVEF. A pattern of rest deformation characterized by worse LS and exaggerated CS is most strongly associated with exercise‐induced rise in PAWP.
Source: European Journal of Heart Failure - October 31, 2016 Category: Cardiology Authors: Tor Biering ‐Sørensen, Mário Santos, Jose Rivero, Shane D. McCullough, Erin West, Alexander R. Opotowsky, Aaron B. Waxman, David M. Systrom, Amil M. Shah Tags: Original Article Source Type: research

Prognostic importance of left ventricular mechanical dyssynchrony in heart failure with preserved ejection fraction
ConclusionWorse LV mechanical dyssynchrony, assessed by speckle tracking echocardiography, is not an independent predictor of adverse outcomes in HFpEF, suggesting that mechanical dyssynchrony is unlikely to be an important mechanism underlying this syndrome. These findings warrant validation in an independent study specifically designed to assess the prognostic utility of mechanical dyssynchrony in HFpEF.Trial registration: NCT00094302
Source: European Journal of Heart Failure - March 20, 2017 Category: Cardiology Authors: Tor Biering ‐Sørensen, Sanjiv J. Shah, Inder Anand, Nancy Sweitzer, Brian Claggett, Li Liu, Bertram Pitt, Marc A. Pfeffer, Scott D. Solomon, Amil M. Shah Tags: Original Article Source Type: research

Prediction of right ventricular failure after ventricular assist device implant: systematic review and meta ‐analysis of observational studies
Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implantation is associated with increased morbidity and mortality, but the identification of LVAD candidates at risk for RVF remains challenging. We undertook a systematic review and meta‐analysis of observational studies of risk factors associated with RVF after LVAD implant. Thirty‐six studies published between 1 January 1995 and 30 April 2015, comprising 995 RVF patients out of a pooled final population of 4428 patients, were identified. Meta‐analysed prevalence of post‐LVAD RVF was 35%. A need for mechanical ventilation [odds r...
Source: European Journal of Heart Failure - March 31, 2017 Category: Cardiology Authors: Diego Bellavia, Attilio Iacovoni, Cesare Scardulla, Lorenzo Moja, Michele Pilato, Sudhir S. Kushwaha, Michele Senni, Francesco Clemenza, Valentina Agnese, Calogero Falletta, Giuseppe Romano, Joseph Maalouf, Michael Dandel Tags: Review Source Type: research

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