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Condition: Coronary Heart Disease

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Total 4335 results found since Jan 2013.

Assessing the Performance of the Framingham Stroke Risk Score in the Reasons for Geographic and Racial Differences in Stroke Cohort Clinical Sciences
Conclusions— Although higher FSRS was associated with higher stroke risk, the FSRS overestimated the observed stroke rates in this study, particularly in certain subgroups. This may be because of temporal declines in stroke rates, secular trends in prevention treatments, or differences in populations studied. More accurate estimates of event rates are critical for planning research, including clinical trials, and targeting health-care efforts.
Source: Stroke - May 27, 2014 Category: Neurology Authors: McClure, L. A., Kleindorfer, D. O., Kissela, B. M., Cushman, M., Soliman, E. Z., Howard, G. Tags: Risk Factors for Stroke Clinical Sciences Source Type: research

Nontraditional Serum Lipid Variables and Recurrent Stroke Risk Clinical Sciences
Conclusions— Of various nontraditional lipid variables, elevated baseline triglycerides/HDL-C and total cholesterol/HDL-C ratios predict future vascular risk after a stroke, but only elevated triglycerides/HDL-C ratio is related to risk of recurrent stroke. Future studies should assess the role of triglycerides/HDL-C as a potential therapeutic target for global vascular risk reduction after stroke.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Park, J.-H., Lee, J., Ovbiagele, B. Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults Clinical Sciences
Conclusions—Modifiable risk factors previously established in older populations also account for a large part of stroke in younger adults, with 4 risk factors explaining almost 80% of stroke risk.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00414583.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Annette Aigner, Ulrike Grittner, Arndt Rolfs, Bo Norrving, Bob Siegerink, Markus A. Busch Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Plasma D-Dimer and Incident Ischemic Stroke and Coronary Heart Disease: The Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— A higher basal plasma d-dimer concentration in the general population is a risk marker for ischemic stroke, especially cardioembolic stroke.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Folsom, A. R., Gottesman, R. F., Appiah, D., Shahar, E., Mosley, T. H. Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Acute Coronary Syndromes Clinical Sciences Source Type: research

Heme Iron Intake and Risk of Stroke: A Prospective Study of Men Original Contributions
Conclusions— Findings from this prospective study indicate that a high heme iron intake, particularly in normal weight individuals, may increase the risk of stroke.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Kaluza, J., Wolk, A., Larsson, S. C. Tags: Risk Factors for Stroke, Epidemiology Original Contributions Source Type: research

Social Network, Social Support, and Risk of Incident Stroke: Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— In this sample of US community-dwelling men and women, having a small social network was associated with excess risk of incident stroke. As with other cardiovascular conditions, having a small social network may be associated with a modestly increased risk of incident stroke.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Nagayoshi, M., Everson-Rose, S. A., Iso, H., Mosley, T. H., Rose, K. M., Lutsey, P. L. Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Sickle Cell Trait and Incident Ischemic Stroke in the Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— We observed an increased risk of ischemic stroke in blacks with SCT. Further investigation of the incidence and pathophysiology of stroke in patients with SCT is warranted.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Caughey, M. C., Loehr, L. R., Key, N. S., Derebail, V. K., Gottesman, R. F., Kshirsagar, A. V., Grove, M. L., Heiss, G. Tags: Genetics of Stroke, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Predictors of Stroke in Patients With Impaired Glucose Tolerance: Results From the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial Brief Reports
Conclusions— The most powerful predictors of stroke in patients with impaired glucose tolerance included a combination of established risk factors and novel variables, such as previous venous thromboembolism and elevated waist circumference, allowing moderately effective identification of high-risk individuals.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Preiss, D., Giles, T. D., Thomas, L. E., Sun, J.-L., Haffner, S. M., Holman, R. R., Standl, E., Mazzone, T., Rutten, G. E., Tognoni, G., Chiang, F.-T., McMurray, J. J. V., Califf, R. M. Tags: Cerebrovascular disease/stroke, Risk Factors, Glucose intolerance Brief Reports Source Type: research

Prospective Study of Anxiety and Incident Stroke Clinical Sciences
Conclusions— Higher anxiety symptom levels were associated prospectively with increased risk for incident stroke independent of other risk factors, including depression. Anxiety is a modifiable experience that is highly prevalent among the general population. Its assessment and treatment may contribute to developing more effective preventive and intervention strategies for improving overall cardiovascular health.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Lambiase, M. J., Kubzansky, L. D., Thurston, R. C. Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Incident Stroke Is Associated With Common Carotid Artery Diameter and Not Common Carotid Artery Intima-Media Thickness Clinical Sciences
Conclusions— Although common carotid IMT is not associated with stroke, interadventitial diameter of the common carotid artery is independently associated with first-time incident ischemic stroke even after adjusting for IMT. Our hypothesis that this is in part attributable to the effects of exposure to blood pressure needs confirmation by other studies. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00063440.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Polak, J. F., Sacco, R. L., Post, W. S., Vaidya, D., Arnan, M. K., O'Leary, D. H. Tags: Cerebrovascular disease/stroke, Risk Factors, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks Clinical Sciences
Background and Purpose—Established risk factors do not fully identify patients at risk for recurrent stroke. The SPARCL trial (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) evaluated the effect of atorvastatin on stroke risk in patients with a recent stroke or transient ischemic attack and no known coronary heart disease. This analysis explored the relationships between 13 plasma biomarkers assessed at trial enrollment and the occurrence of outcome strokes.Methods—We conducted a case–cohort study of 2176 participants; 562 had outcome strokes and 1614 were selected randomly from those without outcom...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Peter Ganz, Pierre Amarenco, Larry B. Goldstein, Henrik Sillesen, Weihang Bao, Gregory M. Preston, K. Michael A. Welch Tags: Biomarkers, Proteomics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Coronary Artery Calcification, Intima-Media Thickness, and Ankle-Brachial Index Are Complementary Stroke Predictors Clinical Sciences
Conclusions— CAC, CIMT, and ABI provide complementary information about stroke risk. ABI, which is distinctive in a small subpopulation, had the highest and CIMT, which is distributed across a larger range of values, had the lowest predictive value.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Gronewold, J., Bauer, M., Lehmann, N., Mahabadi, A. A., Kalsch, H., Weimar, C., Berger, K., Moebus, S., Jockel, K.-H., Erbel, R., Hermann, D. M., on behalf of the Heinz Nixdorf Recall Study Investigative Group Tags: Imaging, Computerized tomography and Magnetic Resonance Imaging, Doppler ultrasound, Transcranial Doppler etc., Risk Factors for Stroke Clinical Sciences Source Type: research

Stroke and Circulating Extracellular RNAs Clinical Sciences
Conclusions—This is the largest study of ex-RNAs in relation to stroke using an unbiased approach in an observational cohort and the first large study to examine human small noncoding RNAs beyond miRNAs. These results demonstrate that when studied in a large observational cohort, extracellular miRNAs are associated with stroke risk.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Eric Mick, Ravi Shah, Kahraman Tanriverdi, Venkatesh Murthy, Mark Gerstein, Joel Rozowsky, Robert Kitchen, Martin G. Larson, Daniel Levy, Jane E. Freedman Tags: Gene Expression & Regulation, Ischemic Stroke Original Contributions Source Type: research

Clinical and Demographic Characteristics Associated With Suboptimal Primary Stroke and Transient Ischemic Attack Prevention Clinical Sciences
Conclusions—Knowing the patient characteristics predictive of missed opportunities for stroke prevention may help primary care identify and appropriately manage these patients. Improving the management of these groups may reduce their risk and potentially prevent large number of future strokes and TIAs in the population.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Grace M. Turner, Melanie Calvert, Max G. Feltham, Ronan Ryan, Samuel Finnikin, Tom Marshall Tags: Epidemiology, Primary Prevention, Hypertension, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Effect of High-Dose Atorvastatin on Renal Function in Subjects With Stroke or Transient Ischemic Attack in the SPARCL Trial Clinical Sciences
Conclusions— This post hoc analysis suggests that atorvastatin treatment may improve renal function in patients with prior stroke or transient ischemic attack with and without chronic kidney disease, and that atorvastatin treatment may prevent eGFR decline in patients with stroke and diabetes mellitus. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00147602.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Amarenco, P., Callahan, A., Campese, V. M., Goldstein, L. B., Hennerici, M. G., Messig, M., Sillesen, H., Welch, K. M. A., Wilson, D. J., Zivin, J. A. Tags: Lipids, Secondary prevention, Cerebrovascular disease/stroke Clinical Sciences Source Type: research