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Role Of Glp-1 Analogs In The Management Of Diabetes And Its Secondary Complication
Mini Rev Med Chem. 2021 Apr 21. doi: 10.2174/1389557521666210422114909. Online ahead of print.ABSTRACTThe cardiovascular complications of type 2 diabetes mellitus (T2DM) include myocardial infarction, heart failure, peripheral vascular disease and, stroke and retinopathy, nephropathy and neuropathy are microvascular complications. While the newer therapies like glitazones or even dipeptidyl-peptidase-IV (DPP-IV) inhibitors increase the risk of therapy, the Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs), were reported as suitable alternates. The GLP-1RAs reduce the major adverse cardiovascular events (MACE), have anti...
Source: Mini Reviews in Medicinal Chemistry - April 23, 2021 Category: Chemistry Authors: Ponnurengam Malliappan Sivakumar B Premkumar Prabhawathi Veluchamy Pranav Kumar Prabhakar Source Type: research

Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Circulation. 2021 Jun 21:CIR0000000000000988. doi: 10.1161/CIR.0000000000000988. Online ahead of print.ABSTRACTObstructive sleep apnea (OSA) is characterized by recurrent complete and partial upper airway obstructive events, resulting in intermittent hypoxemia, autonomic fluctuation, and sleep fragmentation. Approximately 34% and 17% of middle-aged men and women, respectively, meet the diagnostic criteria for OSA. Sleep disturbances are common and underdiagnosed among middle-aged and older adults, and the prevalence varies by race/ethnicity, sex, and obesity status. OSA prevalence is as high as 40% to 80% in patients with ...
Source: Circulation - June 21, 2021 Category: Cardiology Authors: Yerem Yeghiazarians Hani Jneid Jeremy R Tietjens Susan Redline Devin L Brown Nabil El-Sherif Reena Mehra Biykem Bozkurt Chiadi Ericson Ndumele Virend K Somers American Heart Association Council on Clinical Cardiology; Council on Peripheral Vascular Diseas Source Type: research

Transitioning to GLP-1 RAs and SGLT2 Inhibitors as the First Choice for Managing Cardiometabolic Risk in Type 2 Diabetes
Abstract  Purpose of ReviewThis forward-looking review summarizes existing evidence from cardiovascular outcome trials on cardiometabolic risk-reduction in type 2 diabetes (T2DM) management, with attention to updating and personalizing recommendations from recent diabetes practice guidelines issued by cardiology societies.Recent FindingsT2DM management has shifted towards cardiometabolic outcome improvement rather than purely glycemic control. According to large clinical trials, sodium-glucose cotransporter-2 inhibitors showed robust results in reducing heart failure (HF) hospitalization and chronic kidney disease (CKD) p...
Source: Current Atherosclerosis Reports - November 24, 2022 Category: Cardiology Source Type: research

Hypertension
is the most common modifiable risk factor for cardiovascular disease. Antihypertensive treatment substantially reduces the risk of heart failure, stroke, and myocardial infarction. Current guidelines recommend screening all adults for high blood pressure (BP). Lifestyle modifications to help control high BP include weight loss, exercise, moderation of alcohol intake, and a diet low in sodium and saturated fats and high in fruits and vegetables. Out-of-office BP monitoring should be used to confirm suspected white coat effect, especially in patients with apparent resistant hypertension.
Source: Primary Care: Clinics in Office Practice - December 26, 2012 Category: Primary Care Authors: Katherine H. Winter, Laura A. Tuttle, Anthony J. Viera Source Type: research

Hypertension.
Abstract Hypertension is the most common modifiable risk factor for cardiovascular disease. Antihypertensive treatment substantially reduces the risk of heart failure, stroke, and myocardial infarction. Current guidelines recommend screening all adults for high blood pressure (BP). Lifestyle modifications to help control high BP include weight loss, exercise, moderation of alcohol intake, and a diet low in sodium and saturated fats and high in fruits and vegetables. Out-of-office BP monitoring should be used to confirm suspected white coat effect, especially in patients with apparent resistant hypertension. P...
Source: Primary Care - February 21, 2013 Category: Primary Care Authors: Winter KH, Tuttle LA, Viera AJ Tags: Prim Care Source Type: research

Just a few extra pounds increases heart failure risk
Conclusion This large study uses an interesting genetic approach (Mendelian randomisation) to suggest obesity increases the risk of heart failure and adverse changes in liver enzymes. The combination of a very large sample, prospectively collected information, and a wide range of cardiometabolic measures lend credibility to the findings. The method the researchers used is also thought to reduce the chances of factors other than BMI influencing results, and the chance that the ‘outcome’ could be causing the ‘exposure’ (reverse causality). The main limitation of this kind of research is that assumptions need to be m...
Source: NHS News Feed - June 26, 2013 Category: Consumer Health News Tags: Obesity Lifestyle/exercise Source Type: news

Guideline: ACP recommends weight loss and CPAP therapy for obstructive sleep apnea
People diagnosed with obstructive sleep apnea (OSA) should not consider surgery, according to new recommendations from the American College of Physicians (ACP). Instead, ACP recommends that patients lose weight and use continuous positive airway pressure (CPAP) as initial therapy. More than 18 million American adults have sleep apnea, which increases the risk of high blood pressure, heart attack, stroke, heart failure, and diabetes and increases the chance of driving or other accidents. Sleep apnea is a leading cause of excessive daytime sleepiness...
Source: Health News from Medical News Today - September 25, 2013 Category: Consumer Health News Tags: Sleep / Sleep Disorders / Insomnia Source Type: news

In women, increased dietary antioxidants are associated with reduced risk of developing heart failure
Commentary on Rautiainen S, Levitan EB, Mittleman MA, et al.. Total antioxidant capacity of diet and risk of heart failure: a population-based prospective cohort of women. Am J Med 2013;126:494–500. Implications for practice and research A diet rich in natural antioxidants may reduce the risk of developing heart failure. Well-designed intervention studies are needed to investigate the effect of a diet rich in antioxidants on heart failure incidence. Context Heart failure is a syndrome comprising symptoms such as breathlessness alongside objective evidence of cardiac dysfunction. This is a common condition with a cons...
Source: Evidence-Based Nursing - June 17, 2014 Category: Nursing Authors: McKeown, P., McKeag, N. Tags: Drugs: cardiovascular system, Heart failure, Stroke, Diet, Vitamins and supplements, Ischaemic heart disease, Diabetes, Medical humanities, Alcohol, Health education, Smoking, Health effects of tobacco use, Tobacco use Women ' s health Source Type: research

Changes in ventricular‐arterial coupling during decongestive therapy in acute heart failure
ConclusionAn early improvement in ventricular‐arterial coupling was observed after diuretic‐related decongestive therapy in ADHF patients, and was related to decreased effective arterial elastance rather than to change in LV contractility.This article is protected by copyright. All rights reserved.
Source: European Journal of Clinical Investigation - September 1, 2014 Category: Journals (General) Authors: E Berthelot, N Bihry, O Brault‐Melin, P Assayag, A Cohen‐Solal, D Chemla, D Logeart Tags: Original Paper Source Type: research

Changes in ventricular–arterial coupling during decongestive therapy in acute heart failure
ConclusionAn early improvement in ventricular–arterial coupling was observed after diuretic‐related decongestive therapy in ADHF patients and was related to a decrease in effective arterial elastance rather than to change in LV contractility.
Source: European Journal of Clinical Investigation - September 26, 2014 Category: Journals (General) Authors: Emmanuelle Berthelot, Nicolas Bihry, Ophelie Brault‐Melin, Patrick Assayag, Alain Cohen‐Solal, Denis Chemla, Damien Logeart Tags: Original Article Source Type: research

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