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Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy
Sex ‐specific patterns in transcriptome regulation. AbstractHeart disease remains the number one killer of women in the US. Nonetheless, studies in women and female animal models continue to be underrepresented in cardiac research. Hypertrophic cardiomyopathy (HCM), the most commonly inherited cardiac disorder, has been tied to sarcomeric protein variants in both sexes. Among the susceptible genes,TNNC1—encoding cardiac troponin C (cTnC)—causes a substantial HCM phenotype in mice. Mice bearing an HCM‐associated cTnC‐A8V point mutation exhibited a significant decrease in stroke volume and left ventricular diameter...
Source: Physiological Reports - March 20, 2020 Category: Physiology Authors: Karissa M. Dieseldorff Jones, Cynthia Vied, Isela C. Valera, P. Bryant Chase, Michelle S. Parvatiyar, Jose R. Pinto Tags: ORIGINAL RESEARCH Source Type: research

Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N ′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke
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Source: Archives of Physiology and Biochemistry - August 30, 2019 Category: Physiology Authors: Kais Mnafgui Emna Khdhiri Lakhdar Ghazouani Marwa Ncir Zouhaier Zaafouri Noureddine Allouche Abdelfattah Elfeki Houcine Ammar Souhir Abid Raouf Hajji Source Type: research

Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N ?-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke
Volume 127, Issue 6, December 2021, Page 527-540 .
Source: Archives of Physiology and Biochemistry - August 30, 2019 Category: Physiology Authors: Kais Mnafgui Emna Khdhiri Lakhdar Ghazouani Marwa Ncir Zouhaier Zaafouri Noureddine Allouche Abdelfattah Elfeki Houcine Ammar Souhir Abid Raouf Hajji Source Type: research

Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N ′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke
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Source: Archives of Physiology and Biochemistry - August 29, 2019 Category: Physiology Authors: Kais Mnafgui Emna Khdhiri Lakhdar Ghazouani Marwa Ncir Zouhaier Zaafouri Noureddine Allouche Abdelfattah Elfeki Houcine Ammar Souhir Abid Raouf Hajji Source Type: research

An Evaluation of Personal Cooling Systems for Reducing Thermal Strain Whilst Working in Chemical/Biological Protective Clothing
Conclusion: The IV, PCM, and SLIV produced lower heart rate, mean skin, rectal and mean body temperatures in addition to improved work times compared to control. The WS did not improve work times possibly as a result of the cooling capacity of the suit abating, and magnifying thermal insulation. Considering the added time and resources required to implement combination cooling in the form of ice slurry and ice vest (SLIV), there was no significant additive effect for perception, cardiovascular strain, rectal temperature and total trial time relative to the phase change vest or ice vest alone. This may be a product of a &#x...
Source: Frontiers in Physiology - April 11, 2019 Category: Physiology Source Type: research

The blood pressure‐elevating effect of Red Bull energy drink is mimicked by caffeine but through different hemodynamic pathways
Abstract The energy drink Red Bull (RB) has recently been shown to elevate resting blood pressure (BP) and double product (reflecting increased myocardial load). However, the extent to which these effects can be explained by the drink's caffeine and sugar content remains to be determined. We compared the cardiovascular impact of RB to those of a comparable amount of caffeine, and its sugar‐free version in eight young healthy men. Participants attended four experimental sessions on separate days according to a placebo‐controlled randomized crossover study design. Beat‐to‐beat hemodynamic measurements were made conti...
Source: Physiological Reports - February 25, 2015 Category: Physiology Authors: Jennifer L. Miles‐Chan, Nathalie Charrière, Erik K. Grasser, Jean‐Pierre Montani, Abdul G. Dulloo Tags: Original Research Source Type: research