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Mitochondrial medicine therapies: rationale, evidence, and dosing guidelines
Purpose of review
Primary mitochondrial disease is a highly heterogeneous but collectively common inherited metabolic disorder, affecting at least one in 4300 individuals. Therapeutic management of mitochondrial disease typically involves empiric prescription of enzymatic cofactors, antioxidants, and amino acid and other nutrient supplements, based on biochemical reasoning, historical experience, and consensus expert opinion. As the field continues to rapidly advance, we review here the preclinical and clinical evidence, and specific dosing guidelines, for common mitochondrial medicine therapies to guide practitioners ...
Source: Current Opinion in Pediatrics - November 11, 2020 Category: Pediatrics Tags: GENETICS: Edited by Nathaniel H. Robin Source Type: research
