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Immunoregulation of Ghrelin in neurocognitive sequelae associated with COVID-19: an in silico investigation
In this study, we explored, by bioinformatics approaches, the interaction between the multiple inflammatory agents involved in SARS-CoV-2 and Ghrelin (Ghre) together with its receptor GHSR-1A, which are described as anti-inflammatory mediators, in order to investigate what could trigger the hyper-inflammatory response in some SARS-CoV-2 patients. In our analysis, we found several interactions of Ghre and GHSR-1A with SARS-CoV-2 interacting human genes. We observed a correlation between Ghre, angiotensin-converting enzyme 2 ACE2, toll-like receptors 9 (TLR9), and Acidic chitinase (CHIA), whereas its receptor GHSR-1A interac...
Source: Gene - June 9, 2022 Category: Genetics & Stem Cells Authors: Cristina Russo Giovanna Morello Giuliana Mannino Antonella Russo Lucia Malaguarnera Source Type: research