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Top 20 Research Studies of 2022 for Primary Care Physicians
This article summarizes the top 20 research studies of 2022 identified as POEMs (patient-oriented evidence that matters), excluding COVID-19. Statins for primary prevention of cardiovascular disease produce only a small absolute reduction in a person's likelihood of dying (0.6%), having a myocardial infarction (0.7%), or having a stroke (0.3%) over three to six years. Supplemental vitamin D does not reduce the risk of a fragility fracture, even in people with low baseline vitamin D levels or a previous fracture. Selective serotonin reuptake inhibitors are preferred medical therapy for panic disorder, and patients who disco...
Source: American Family Physician - April 13, 2023 Category: Primary Care Authors: Roland Grad Mark H Ebell Source Type: research

An Evidence-Based Review of Vitamin D for Common and High-Mortality Conditions
Conclusion: Prospective studies of vitamin D supplementation demonstrate variable impact on disease specific and patient-oriented outcomes, suggesting a correlation but not a causal relationship between low vitamin D levels and disease pathogenicity. Future research should determine dosing standards and timing of vitamin D in treatment and prevention.
Source: Journal of the American Board of Family Medicine - December 23, 2022 Category: Primary Care Authors: Michael, W., Couture, A. D., Swedlund, M., Hampton, A., Eglash, A., Schrager, S. Tags: Clinical Review Source Type: research

The role of rehabilitation and vitamin D supplementation on motor and psychological outcomes in poststroke patients
Post-Stroke depression affects between 12% and 72% of patients who have suffered a stroke. The association between low serum levels of 25-hydroxyvitamin D (25(OH) D) and increased risk of depression is reported in both stroke and non-stroke patients. Similarly, high 25(OH) D levels might be associated with greater functional improvement during rehabilitation program. We wanted to investigate the effects of an intensive rehabilitation on poststroke outcomes. We wondered if the daily rehabilitation of motor and cognitive functions could also have an effect on mood and functional abilities in addition to or as an alternati...
Source: Medicine - November 12, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Neurosteroids: a novel promise for the treatment of stroke and post ‐stroke complications
AbstractStroke is the primary reason for death and disability worldwide, with few treatment strategies to date. Neurosteroids, which are natural molecules in the brain, have aroused great interest in the field of stroke. Neurosteroids are a kind of steroid that acts on the nervous system, and are synthesized in the mitochondria of neurons or glial cells using cholesterol or other steroidal precursors. Neurosteroids mainly include estrogen, progesterone (PROG), allopregnanolone, dehydroepiandrosterone (DHEA), and vitamin D (VD). Most of the preclinical studies have confirmed that neurosteroids can decrease the risk of strok...
Source: Journal of Neurochemistry - September 5, 2021 Category: Neuroscience Authors: Jiawei Xu, Yunxiang Zhou, Caochong Yan, Xiaoyu Wang, Jianyao Lou, Yi Luo, Shiqi Gao, Junjie Wang, Liang Wu, Xiangfu Gao, Anwen Shao Tags: REVIEW ARTICLE Source Type: research

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