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Early Detection of Subclinical Atherosclerosis: Hyperhomocysteinemia as a Promising Marker in Adolescents With Vitamin B Deficiency
Cureus. 2023 Jul 8;15(7):e41571. doi: 10.7759/cureus.41571. eCollection 2023 Jul.ABSTRACTIn recent decades, the increased incidence of cardiovascular disease (CVD) mortality among young adults has raised concerns. Although clinical manifestations of CVD typically occur later in life, the underlying pathological processes emerge early on. This review article summarizes the association between vitamin B deficiency-induced hyperhomocysteinemia and subclinical atherosclerosis in adolescents. Numerous studies have demonstrated that elevated homocysteine levels are an independent risk factor for endothelial dysfunction (ED) and ...
Source: Atherosclerosis - August 9, 2023 Category: Cardiology Authors: Parth S Shirode Anjali D Parekh Vishwa V Patel Janmay Vala Aniket M Jaimalani Nilofar M Vora Vaishnavi Gummalla Jaineel S Patel Nikitha Shriram Source Type: research

Effects of vitamin B < sub > 12 < /sub > deficiency on risk and outcome of ischemic stroke
Clin Biochem. 2023 May 27:110591. doi: 10.1016/j.clinbiochem.2023.110591. Online ahead of print.ABSTRACTIschemic stroke is the most prevalent form of stroke and has a high incidence in older adults, characterized by high morbidity, mortality, disability, and recurrence rate. Vitamin B12 deficiency is prevalent in the elderly and has been reported to be associated with ischemic stroke. The mechanisms maybe include the disorder of methylation metabolism, accumulation of toxic metabolites, immune dysfunction, affecting gut microbial composition and gut-brain immune homeostasis, and toxic stress responses to the brain. Vitamin...
Source: Atherosclerosis - May 29, 2023 Category: Cardiology Authors: Li Zhou Xiaosong Song Jiani Wang Yongjun Tan Qin Yang Source Type: research

The Controversial Role of HCY and Vitamin B Deficiency in Cardiovascular Diseases
Nutrients. 2022 Mar 28;14(7):1412. doi: 10.3390/nu14071412.ABSTRACTPlasma homocysteine (HCY) is an established risk factor for cardiovascular disease CVD and stroke. However, more than two decades of intensive research activities has failed to demonstrate that Hcy lowering through B-vitamin supplementation results in a reduction in CVD risk. Therefore, doubts about a causal involvement of hyperhomocysteinemia (HHcy) and B-vitamin deficiencies in atherosclerosis persist. Existing evidence indicates that HHcy increases oxidative stress, causes endoplasmatic reticulum (ER) stress, alters DNA methylation and, thus, modulates t...
Source: Atherosclerosis - April 12, 2022 Category: Cardiology Authors: Wolfgang Herrmann Markus Herrmann Source Type: research

Relation between vitamin B12 and SYNTAX Score.
CONCLUSION: In our study, we found significant relationship between vitamin B12 deficiency and SYNTAX score demonstrating the severity and complexity of coronary artery disease. PMID: 27391912 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - July 7, 2016 Category: Cardiology Authors: Cerit L, Duygu H, Gulsen K, Kemal H, Tosun O, Ozcem B, Cerit Z, Gunsel A Tags: Kardiol Pol Source Type: research

Large analysis reopens theory of vitamin-B supplementation and stroke 
An updated meta-analysis finds that taking B vitamins to lower homocysteine levels has a significant impact on stroke. Factors such as hypertension and kidney disease may play a role.
Source: theHeart.org - September 19, 2013 Category: Cardiology Source Type: news

Vitamin B Supplements May Guard Against Stroke
Title: Vitamin B Supplements May Guard Against StrokeCategory: Health NewsCreated: 9/18/2013 4:35:00 PMLast Editorial Review: 9/19/2013 12:00:00 AM
Source: MedicineNet Heart General - September 19, 2013 Category: Cardiology Source Type: news

B Vitamins Trim Stroke Risk for Some (CME/CE)
(MedPage Today) -- Vitamin B supplementation may modestly help reduce stroke risk, though largely for patients who don't fit the typical U.S. stroke prevention profile, a meta-analysis showed.
Source: MedPage Today Cardiovascular - September 18, 2013 Category: Cardiology Source Type: news