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High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging
CONCLUSION: The superior PA signal of Se@PPy nanomaterials can identify the extent of atherosclerotic carotid lesions, demonstrating the feasibility of PA imaging technology in diagnosing carotid thrombosis lesion formation. This study demonstrates nanocomposites and PA techniques for imaging and diagnosing carotid thrombosis in vivo.PMID:37520300 | PMC:PMC10377622 | DOI:10.2147/IJN.S404743
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: Fengbing He Wenzhong Hou Yintao Lan Weijian Gao Mengyu Zhou Jinghang Li Shutong Liu Bin Yang Jian Zhang Source Type: research

The role of glutathione peroxidase-1 in health and disease
Free Radic Biol Med. 2022 Jun 9:S0891-5849(22)00224-6. doi: 10.1016/j.freeradbiomed.2022.06.004. Online ahead of print.ABSTRACTGlutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it has a single redox-sensitive selenocysteine amino acid that is important for the enzymatic reduction of hydrogen peroxide and soluble lipid hydroperoxides. Glutathione provides the source of reducing equivalents for its function. As an antioxidant enzyme, GPx1 modulates the balance between necessary and harmful levels of reactive...
Source: Atherosclerosis - June 12, 2022 Category: Cardiology Authors: Diane E Handy Joseph Loscalzo Source Type: research