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Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options
Mediators Inflamm. 2022 Oct 11;2022:6508046. doi: 10.1155/2022/6508046. eCollection 2022.ABSTRACTThere has been a significant amount of interest in the past two decades in the study of the evolution of the gut microbiota, its internal and external impacts on the gut, and risk factors for cerebrovascular disorders such as cerebral ischemic stroke. The network of bidirectional communication between gut microorganisms and their host is known as the microbiota-gut-brain axis (MGBA). There is mounting evidence that maintaining gut microbiota homeostasis can frequently enhance the effectiveness of ischemic stroke treatment by mo...
Source: Atherosclerosis - October 21, 2022 Category: Cardiology Authors: Wenjing Huang Luwen Zhu Wenjing Song Mei Zhang Lili Teng Minmin Wu Source Type: research

Probiotics Bring New Hope for Atherosclerosis Prevention and Treatment
Oxid Med Cell Longev. 2022 Sep 24;2022:3900835. doi: 10.1155/2022/3900835. eCollection 2022.ABSTRACTCardiovascular disease is the leading cause of human mortality and morbidity worldwide. Atherosclerosis (AS) is the underlying pathological responsible in most acute and severe cardiovascular diseases including myocardial infarction and stroke. However, current drugs applied to the treatment of AS are not clinically effective, and there is a large residual risk of cardiovascular disease and multiple side effects. Increasing evidence supports a close relationship between microorganisms and the incidence of AS. Recent data hav...
Source: Atherosclerosis - October 4, 2022 Category: Cardiology Authors: Taiyu Zhai Pingping Wang Xiumei Hu Lei Zheng Source Type: research

< em > Bifidobacterium breve < /em > and < em > Bifidobacterium longum < /em > Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in Mice
Nutrients. 2022 Mar 14;14(6):1222. doi: 10.3390/nu14061222.ABSTRACTAtherosclerosis is the main cause of myocardial infarction and stroke, and the morbidity and mortality rates of cardiovascular disease are among the highest of any disease worldwide. Excessive plasma trimethylamine-N-oxide (TMAO), an intestinal metabolite, promotes the development of atherosclerosis. Therefore, effective measures for reducing plasma TMAO production can contribute to preventing atherosclerosis. Probiotics are living microorganisms that are beneficial to the human body, and some of them can attenuate plasma TMAO production. To explore the eff...
Source: Atherosclerosis - March 26, 2022 Category: Cardiology Authors: Qianqian Wang Min Guo Yang Liu Mengshu Xu Liuting Shi Xiu Li Jianxin Zhao Hao Zhang Gang Wang Wei Chen Source Type: research