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Phosphoproteome Analysis Identifies a Synaptotagmin-1-associated complex involved in Ischemic Neuron Injury
Mol Cell Proteomics. 2022 Mar 4:100222. doi: 10.1016/j.mcpro.2022.100222. Online ahead of print.ABSTRACTCerebral stroke is one of the leading causes of death in adults worldwide. However, the molecular mechanisms of stroke-induced neuron injury are not fully understood. Here, we obtained phosphoproteomic and proteomic profiles of the acute ischemic hippocampus by LC-MS/MS analysis. Quantitative phosphoproteomic analyses revealed that the dysregulated phosphoproteins were involved in synaptic components and neurotransmission. We further demonstrated that phosphorylation of Synaptotagmin-1 (Syt1) at the Thr112 site in cultur...
Source: Molecular and Cellular Proteomics : MCP - March 8, 2022 Category: Molecular Biology Authors: Wei Jiang Pei Zhang Peng Yang Na Kang Junqiang Liu Aihemaiti Yilixiati Haijun Tu Source Type: research