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Triclosan is a KCNQ3 potassium channel activator
Pflugers Arch. 2022 Apr 22. doi: 10.1007/s00424-022-02692-w. Online ahead of print.ABSTRACTKCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and 5. Activation of these channels silence the neurons, limiting action potential duration and preventing high-frequency action potential burst. Loss-of-function mutations of the KCNQ channels are associated with a wide spectrum of phenotypes characterized by hyperexcitability. Hence, pharmacological activation of these channels is an attractive strategy to treat epilepsy and other hyperexci...
Source: Pflugers Archiv : European Journal of Physiology - April 23, 2022 Category: Physiology Authors: Victor De la Rosa Maria Luisa Guzm án-Hernández Elisa Carrillo Source Type: research

The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration.
Abstract Potassium channels can fulfill both beneficial and detrimental roles in neuronal damage during ischemic stroke. Earlier studies have characterized a neuroprotective role of the two-pore domain potassium channels KCNK2 (TREK1) and KCNK3 (TASK1). Protective neuronal hyperpolarization and prevention of intracellular Ca(2+) overload and glutamate excitotoxicity were suggested to be the underlying mechanisms. We here identify an unexpected role for the related KCNK5 channel in a mouse model of transient middle cerebral artery occlusion (tMCAO). KCNK5 is strongly upregulated on neurons upon cerebral ischemia, w...
Source: Pflugers Archiv : European Journal of Physiology - October 15, 2014 Category: Physiology Authors: Göb E, Bittner S, Bobak N, Kraft P, Göbel K, Langhauser F, Homola GA, Brede M, Budde T, Meuth SG, Kleinschnitz C Tags: Pflugers Arch Source Type: research