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Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large ‑vessel ischemic stroke.
Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large‑vessel ischemic stroke. Mol Med Rep. 2019 Feb 25;: Authors: Janicki PK, Eyileten C, Ruiz-Velasco V, Pordzik J, Czlonkowska A, Kurkowska-Jastrzebska I, Sugino S, Imamura Kawasawa Y, Mirowska-Guzel D, Postula M Abstract The impact of rare and damaging variants in genes associated with platelet function in large‑vessel ischemic stroke (LVIS) remains unknown. The aim of this study was to investigate the contribution of some of these variants to the genetic susceptibility to LVIS in Polish patients using a deep re‑...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Frequency and predictors of post-stroke delirium in PRospective Observational POLIsh Study (PROPOLIS)
AbstractDelirium is the most common and serious neurobehavioral complication in acute hospital admissions. Some patients develop signs of delirium but do not meet all diagnostic criteria. Stroke is a major risk factor for delirium. The aim of this prospective study was to build a predictive model for delirium and subsyndromal post-stroke delirium. Patients with stroke were screened for delirium during the first 7  days after admission. Delirium was diagnosed according to DSM-V criteria. Baseline demographic, biochemical, stroke-related data, medications used, neurological deficit, and premorbid cognitive and functional im...
Source: Journal of Neurology - February 8, 2018 Category: Neurology Source Type: research