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Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)
CONCLUSION: Ginseng was well tolerated by patients with severe atherosclerosis, with these patients showing good compliance with ginseng dosing. Ginseng did not show significant effects compared with placebo, although none of the ginseng-treated patients experienced ischemic events. Long-term studies in larger patient populations are required to test the effect of ginseng.PMID:35818424 | PMC:PMC9270648 | DOI:10.1016/j.jgr.2021.11.002
Source: Atherosclerosis - July 12, 2022 Category: Cardiology Authors: Boseong Kwon Yunsun Song Joong-Goo Kim Dongwhane Lee Sang-Hun Lee Young-Keol Cho Jong S Kim Dae Chul Suh Source Type: research

Protective Effects and Therapeutics of Ginsenosides for Improving Endothelial Dysfunction: From Therapeutic Potentials, Pharmaceutical Developments to Clinical Trials
Am J Chin Med. 2022 Apr 13:1-24. doi: 10.1142/S0192415X22500318. Online ahead of print.ABSTRACTThe endothelium covers the internal lumen of the entire circulatory system and plays an important modulatory role in vascular homeostasis. Endothelium dysfunction, characterized by a vasoconstrictive, pro-inflammatory, and pro-coagulant state, usually manifests as a significant pathological process of vascular diseases, including hypertension, atherosclerosis (AS), stroke, diabetes mellitus, coronary artery disease, and cancer. Therefore, there is an urgent necessity to seek promising therapeutic drugs or remedies to ameliorate e...
Source: Atherosclerosis - April 22, 2022 Category: Cardiology Authors: Fang Yang Ming-Yue Yang Jing-Qing Le Bang-Yue Luo Meng-Die Yin None Chao-Li Jia-Li Jiang Yi-Fan Fang Jing-Wei Shao Source Type: research