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Cardiac adaptation to hypertension in adult female Dahl salt ‐sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation
Abstract Aim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt‐dependent hypertension. Dahl salt‐sensitive rats, age 12 weeks, with/without ovariectomy were fed a standard (0.3% NaCl) or high‐salt diet (8%) for 16 weeks. Mean arterial blood pressure monitored noninvasively in conscious state increased significantly by high salt. Echocardiography was performed at baseline and endpoint. Heart function and molecular changes were evaluated at endpoint by left ventricle catheterization, by sirius red staining f...
Source: Physiological Reports - February 8, 2018 Category: Physiology Authors: Stian Ludvigsen, Costantino Mancusi, Simon Kildal, Giovanni Simone, Eva Gerdts, Kirsti Ytrehus Tags: Original Research Source Type: research

Short high ‐fat diet interferes with the physiological maturation of the late adolescent mouse heart
This study suggests that even a short period of high fat intake during late adolescence hinders maturation of the heart and causes physiological changes that may have an impact on the cardiac health in adulthood. AbstractDietary fats are essential for cardiac function. The metabolites of fats known as fatty acids provide most of the energy for cardiac tissue, serve as building blocks for membranes and regulate important signaling cascades. Despite their importance, excess fat intake can cause cardiac dysfunction. The detrimental effects of high ‐fat diet (HFD) on cardiac health are widely investigated in long‐term stud...
Source: Physiological Reports - July 7, 2020 Category: Physiology Authors: Heidi Hynynen, Maija Mutikainen, Nikolay Naumenko, Anastasia Shakirzyanova, Tomi Tuomainen, Pasi Tavi Tags: ORIGINAL RESEARCH Source Type: research

A high salt meal does not impair cerebrovascular reactivity in healthy young adults
A single high sodium meal compared to a low sodium meal does not impair cerebrovascular reactivity to hypercapnia or hypocapnia in healthy adults. MCA, Middle Cerebral Artery. AbstractA high sodium (Na+) meal impairs peripheral vascular function. In rodents, chronic high dietary Na+ impairs cerebral vascular function, and in humans, habitual high dietary Na+ is associated with increased stroke risk. However, the effects of acute high dietary Na+ on the cerebral vasculature in humans are unknown. The purpose of this study was to determine if acute high dietary Na+ impairs cerebrovascular reactivity in healthy adults. Thirty...
Source: Physiological Reports - October 10, 2020 Category: Physiology Authors: Kamila U. Migdal, Austin T. Robinson, Joseph C. Watso, Matthew C. Babcock, Shannon L. Lennon, Christopher R. Martens, Jorge M. Serrador, William B. Farquhar Tags: ORIGINAL RESEARCH Source Type: research

Constrictor responses of cerebral resistance arterioles in male and female rats exposed to prenatal alcohol
Our goal was to examine constrictor responses of cerebral arterioles in rats exposed to prenatal alcohol. We found that constrictor responses were preserved in adolescent and adult rats that were exposed to prenatal alcohol. We suggest that impaired dilation, with preservation of constriction, may favor a scenario leading to cerebral ischemia, and perhaps stroke. AbstractWhile it is known that dilation of cerebral arterioles to NOS-dependent agonists is impaired in rats exposed to prenatal alcohol, no studies have examined the influence of prenatal alcohol on constrictor response of cerebral arterioles. Our goal was to det...
Source: Physiological Reports - October 29, 2021 Category: Physiology Authors: Partha S. Saha, Tiffany M. Knecht, Denise M. Arrick, Michael J. Watt, Jamie L. Scholl, William G. Mayhan Tags: ORIGINAL ARTICLE Source Type: research

Modulation of blood pressure regulatory genes in the Agtrap ‐Plod1 locus associated with a deletion in Clcn6
In this study, we tested whether loss ofClcn6 would be protective against high salt-induced mortality. While we observed no significant differences in longevity or neuronal cell death between the SS-Clcn6 knock-out and SS-WT groups, we found that a mutation inClcn6 could be associated with changes to mRNA expression of nearbyMthfr,Nppa, andNppb genes, thereby complicating the genetic phenotype of our knockout animal. AbstractThe AGTRAP-PLOD1 locus is a conserved gene cluster containing several blood pressure regulatory genes, includingCLCN6,MTHFR,NPPA, andNPPB. Previous work revealed that knockout ofClcn6 on the Dahl Salt-...
Source: Physiological Reports - August 5, 2022 Category: Physiology Authors: Christine A. Klemens, Lashodya V. Dissanayake, Vladislav Levchenko, Adrian Zietara, Oleg Palygin, Alexander Staruschenko Tags: ORIGINAL ARTICLE Source Type: research