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Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options
Mediators Inflamm. 2022 Oct 11;2022:6508046. doi: 10.1155/2022/6508046. eCollection 2022.ABSTRACTThere has been a significant amount of interest in the past two decades in the study of the evolution of the gut microbiota, its internal and external impacts on the gut, and risk factors for cerebrovascular disorders such as cerebral ischemic stroke. The network of bidirectional communication between gut microorganisms and their host is known as the microbiota-gut-brain axis (MGBA). There is mounting evidence that maintaining gut microbiota homeostasis can frequently enhance the effectiveness of ischemic stroke treatment by mo...
Source: Atherosclerosis - October 21, 2022 Category: Cardiology Authors: Wenjing Huang Luwen Zhu Wenjing Song Mei Zhang Lili Teng Minmin Wu Source Type: research

The enigmatic role of VCAM-1 expressed by macrophages in mitochondrial metabolism and atherosclerosis
CONCLUSION: We conclude that macrophage-specific VCAM-1 augments mitochondrial biogenesis and DNA oxidation via Cmpk2. Oxidized mitochondrial DNA in plaque macrophages increases inflammation via Sting, resulting in exacerbation of atherosclerosis.PMID:35557156 | DOI:10.1096/fasebj.2022.36.S1.R6141
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Niranjana Natarajan Jonathan Florentin Scott P O'Neil Lee L Ohayon Partha Dutta Source Type: research