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Source: Atherosclerosis
Drug: Gilenya
Nutrition: Diets
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Total 2 results found since Jan 2013.
Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities
This study used a rigorous study design in normal male C57BL/6JOlaHsd mice and in mice with common stroke comorbidities to further evaluate the translational potential of fingolimod. Stroke was induced via middle cerebral artery electrocoagulation in 8-9-week old mice (young mice), 18 month old mice (aged mice), and in high-fat diet-fed 22-week old ApoE-/- mice (hyperlipidaemic mice). Recovery was evaluated using motor behavioural tests 3 and 7 days after stroke. Tissue damage was evaluated at 7 days. A lower dose of fingolimod, 0.5 mg/kg, but not 1 mg/kg, increased lesion size but decreased ipsilateral brain atrophy in yo...
Source: Atherosclerosis - August 1, 2022 Category: Cardiology Authors: Andrea C Diaz Diaz Kyle Malone Jennifer A Shearer Anne C Moore Christian Waeber Source Type: research
