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An Enriched Environment Promotes Motor Function through Neuroprotection after Cerebral Ischemia
In this study, adult C57BL/6 mice after permanent middle cerebral artery occlusion (pMCAO) were assigned to the EE and standard housing (SH) groups 3 days after operation. The EE house was spacious that contained a large variety of small toys; the SH was a normal sized cage. Sham-operated mice without artery occlusion were housed under standard conditions and were fed a normal diet. On days 3, 7, 14, and 21, postoperative motor functional recovery was tested using the modified neurological severity score (mNSS) and the Rotarod test. The expression of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), growth-assoc...
Source: Cell Research - February 23, 2023 Category: Cytology Authors: Liang-Feng Shi Chuan-Jie Wang Ke-Wei Yu Jun-Fa Wu Qi-Qi Zhang Source Type: research