• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF- κB signaling pathway
CONCLUSIONS: These findings indicate that ICT plays roles in inhibiting the inflammatory response and achieving neuroprotection by regulating GPER-ERK-NF-κB signaling and then inhibiting microglial activation and M1 polarization while promoting M2 polarization, which provides a new therapeutic for against cerebral ischemic stroke.PMID:36447154 | DOI:10.1186/s10020-022-00573-7
Source: Molecular Medicine - November 29, 2022 Category: Molecular Biology Authors: Zining Yu Guangjun Su Limei Zhang Gaigai Liu Yonggang Zhou Shicai Fang Qian Zhang Tianyun Wang Cheng Huang Zhihua Huang Liangdong Li Source Type: research

Antihypertension effect of astragaloside  IV during cerebral ischemia reperfusion in rats
In conclusion, astragaloside IV may alleviate CIR injury partially by lowering systemic blood pressure.PMID:36331022 | DOI:10.3892/mmr.2022.12890
Source: Molecular Medicine - November 4, 2022 Category: Molecular Biology Authors: Fengyan Shen Yong Meng Yuhai He Bowan Huang Jinxin Huang Lu Wang Source Type: research

Mechanism of ischemic brain injury repair by endothelial progenitor cell ‑derived exosomes
Mol Med Rep. 2022 Aug;26(2):269. doi: 10.3892/mmr.2022.12785. Epub 2022 Jul 1.ABSTRACTIschemic stroke is a refractory disease that seriously endangers human health and life. The main treatment aim of stroke is to alleviate brain injury. The present study aimed to investigate the effects and mechanisms of endothelial progenitor cell (EPC)‑derived exosomes in repairing ischemic brain injury. Sprague‑Dawley rat models of cerebral ischemia‑reperfusion (IR) injury were established by middle cerebral artery occlusion. The IR model rats were then treated with PBS, EPC or exosomes; untreated and Sham rats were used as contro...
Source: Molecular Medicine - July 1, 2022 Category: Molecular Biology Authors: Rui Huang Tianxiang Cheng Xianliang Lai Source Type: research

Damage to the blood ‑brain barrier and activation of neuroinflammation by focal cerebral ischemia under hyperglycemic condition
Int J Mol Med. 2021 Jul;48(1):142. doi: 10.3892/ijmm.2021.4975. Epub 2021 Jun 3.ABSTRACTHyperglycemia aggravates brain damage caused by cerebral ischemia/reperfusion (I/R) and increases the permeability of the blood‑brain barrier (BBB). However, there are relatively few studies on morphological changes of the BBB. The present study aimed to investigate the effect of hyperglycemia on BBB morphological changes following cerebral I/R injury. Streptozotocin‑induced hyperglycemic and citrate‑buffered saline‑injected normoglycemic rats were subjected to 30 min middle cerebral artery occlusion. Neurological deficits were ...
Source: Molecular Medicine - June 3, 2021 Category: Molecular Biology Authors: Yongzhen Guo Lingdi Dong Ao Gong Jingwen Zhang Li Jing Tomas Ding Ping-An Andy Li Jian-Zhong Zhang Source Type: research

Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway.
This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluate...
Source: Molecular Medicine - March 24, 2019 Category: Molecular Biology Authors: Luo S, Li H, Mo Z, Lei J, Zhu L, Huang Y, Fu R, Li C, Huang Y, Liu K, Chen W, Zhang L Tags: Exp Mol Med Source Type: research