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MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway
ConclusionsOur data demonstrated that miR-130a prevented cerebral I/R damage by mediating the PTEN/PI3K/AKT axis. These preliminarily findings furthered our understanding of this mechanism and identified new potential therapeutic targets for ischemic stroke.
Source: Biomedicine and Pharmacotherapy - June 19, 2019 Category: Drugs & Pharmacology Source Type: research

Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury
In this study, we investigated the effects of IL-11 on cerebral ischemia-reperfusion injury in a model of focal cerebral ischemia.MethodsMice were randomly divided into five groups the vehicle group, the middle cerebral artery occlusion (MCAO) group, the MCAO plus adenosine monophosphate-activated protein kinase (AMPK) inhibitor compound C group, the MCAO plus IL-11 treatment group, and the MCAO plus IL-11 treatment and compound C group. Focal cerebral ischemia was induced by occluding the left middle cerebral artery, and reperfusion was achieved by withdrawing the suture 2 h after ischemia. The protein expression levels...
Source: Biomedicine and Pharmacotherapy - May 15, 2019 Category: Drugs & Pharmacology Source Type: research