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Very early infective endocarditis after transcatheter aortic valve replacement
ConclusionA significant proportion of IE episodes following TAVR occurs within a few weeks following the procedure and are associated with dismal outcomes. Some baseline and TAVR procedural factors were associated with VE-IE, andStaphylococcus aureus and enterococci were the main causative pathogens. These results may help to select the more appropriate antibiotic prophylaxis in TAVR procedures and guide the initial antibiotic therapy in those cases with a clinical suspicion of IE.Graphical abstractVery early infective endocarditis after trans-catheter aortic valve replacement. VE-IE indicates very early infective endocard...
Source: Clinical Research in Cardiology - March 9, 2022 Category: Cardiology Source Type: research

Prevalence, risk factors and outcomes of patients coming from the community with sepsis due to multidrug resistant bacteria
ConclusionIn light of the prevalence and impact of MDR bacteria causing sepsis in patients coming from the community, physicians should consider ESBL coverage when starting an empiric antibiotic therapy in patients with specific risk factors, especially in the presence of septic shock.
Source: Multidisciplinary Respiratory Medicine - July 4, 2019 Category: Respiratory Medicine Source Type: research

Compartmentalization of Immune Responses during Staphylococcus aureus Cranial Bone Flap Infection.
Abstract Decompressive craniectomy is often required after head trauma, stroke, or cranial bleeding to control subsequent brain swelling and prevent death. The infection rate after cranial bone flap replacement ranges from 0.8% to 15%, with an alarming frequency caused by methicillin-resistant Staphylococcus aureus, which is problematic because of its recalcitrance to antibiotic therapy. Herein we report the establishment of a novel mouse model of S. aureus cranial bone flap infection that mimics several aspects of human disease. Bacteria colonized bone flaps for up to 4 months after infection, as revealed by scan...
Source: The American Journal of Pathology - June 6, 2013 Category: Pathology Authors: Cheatle J, Aldrich A, Thorell WE, Boska MD, Kielian T Tags: Am J Pathol Source Type: research