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Neuropsychological adverse drug reactions of Remdesivir: analysis using VigiBase, the WHO global database of individual case safety reports
CONCLUSIONS: Our study demonstrates that remdesivir, a novel drug applied to the treatment of COVID-19, does not have a significant association with adverse neurologic or psychiatric reactions in the real-world setting.PMID:34919240 | DOI:10.26355/eurrev_202112_27435
Source: Pharmacological Reviews - December 17, 2021 Category: Drugs & Pharmacology Authors: S Lee J W Yang S Y Jung M S Kim D K Yon S W Lee H-C Kang E Dragioti K Tizaoui L Jacob A Koyanagi J-E Salem K Kostev A Lascu J I Shin J H Kim L Smith Source Type: research

Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 Infection
AbstractSARS-CoV-2 infection begins with the attachment of its spike (S) protein to angiotensin-converting enzyme-2 (ACE2) followed by complex host immune responses with cardiovascular and neurological implications. Our meta-analyses used QIAGEN Ingenuity Pathway Analysis (IPA) and Knowledge Base (QKB) to investigate how the expression of amyloid precursor protein (APP) was modulated by attachment of SARS-CoV-2 S protein in the brain microvascular endothelial cells (BMVECs) and during COVID-19 in progress. Published 80 host response genes reported to be modulated in BMVECs following SARS-CoV-2 S protein binding were used t...
Source: Journal of NeuroImmune Pharmacology - November 10, 2021 Category: Drugs & Pharmacology Source Type: research

Outcome after acute ischemic stroke treatment during Covid-19 outbreak in South-East Tuscany
CONCLUSION: During the lockdown period due to Covid-19 pandemic, patients with acute ischemic stroke had a worse prognosis. These findings suggest the need to improve the health system organization to guarantee an appropriate treatment during the pandemic, including the patients that are not affected by Covid-19.PMID:34579640 | DOI:10.2174/1871529X21666210927094058
Source: Cardiovascular and Hematological Disorders Drug Targets - September 28, 2021 Category: Drugs & Pharmacology Authors: Maurizio Acampa Valentina Peresso Pietro Enea Lazzerini Carlo Domenichelli Francesca Guideri Rossana Tassi Stefano Dami Roberto Marconi Giovanni Iannelli Giovanni Linoli Giulia Peppoloni Simone Nocentini Simone Gallerini Alessandra Cartocci Sandra Bracco Source Type: research

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